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Microglia care for neurons through tunneling nanotubes [Dataset 1 Neurons mRNA-seq]

ABSTRACT: Microglia care for neurons through tunneling nanotubes [Dataset 1 Neurons mRNA-seq]

PROVIDER: PRJNA863252 | ENA |

REPOSITORIES: ENA

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Microglia care for neurons through tunneling nanotubes

Project description:Microglia care for neurons through tunneling nanotubes

| PRJNA863248 | ENA

Microglia care for neurons through tunneling nanotubes [Dataset 2 Microglia mRNA-seq]

Project description:Microglia care for neurons through tunneling nanotubes [Dataset 2 Microglia mRNA-seq]

| PRJNA863253 | ENA

Microglia care for neurons through tunneling nanotubes [Dataset 2 Microglia mRNA-seq]

Project description:We report the transfer of alpha-s-ynuclein aggregates from neurons to microglia and examined transcriptomic changes following protein extraction. By obtaining RNA samples, we performed differential expression analysis and generated gene ontology enrichment and network analysis.

2023-12-01 | GSE209971 | GEO

Microglia care for neurons through tunneling nanotubes [Dataset 1 Neurons mRNA-seq]

2023-12-01 | GSE209970 | GEO

Microglia care for neurons through tunneling nanotubes

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-12-01 | GSE209972 | GEO

Gene expression in spinal cord neurons grown on polyornithine or on carbon nanotube (CNT)-based substrates

Project description:Carbon nanotubes are cylindrically-shaped carbon nanostructures, made up of layers of graphene rolled onto themselves, with diameters similar to those of neuronal processes. In the last decade, CNT have been used as biocompatible growing substrates for neuronal attachment, differentiation and growth. In the perspective of new developments in tissue engineering, and in particular in spinal cord repair strategies, based on the use of CNTs, our aim is to clarify the biophysical interactions between CNTs and spinal cord neurons, studying the development of the morphological and functional characteristics of spinal neurons grown on CNT-based interfaces. In this context, we used microarrays to show whether cultured dissociated spinal neurons show a difference in gene expression when grown in control conditions (polyornithine-covered substrates) or on CNT-based substrates. Gene expression profiling was evaluated from 3 replicates each of neurons grown on nanotubes and control conditions.

2013-08-05 | E-GEOD-27212 | biostudies-arrayexpress

Tunneling nanotubes contribute to the stroma-mediated imatinib resistance of leukemic cells

Project description:Intercellular communication within the bone marrow niche significantly influences leukemogenesis and the sensitivity of leukemic cells to therapy. However, the landscape of possible cell-cell interactions is still incomplete. Tunneling nanotubes (TNTs) are a novel mode of intercellular cross-talk. They are long, thin membranous conduits that enable the direct transfer of various cargo between cells. The present study found that TNTs are formed between leukemic and bone marrow stromal cells. Confocal three-dimensional reconstructions, correlative light-electron microscopy, and electron tomography provided evidence that TNTs transfer cellular vesicles between cells. The quantitative analysis demonstrated the stimulation of TNT-mediated vesicle transfer from stromal cells to leukemic cells by the stromal component. The vesicular cargo that was received from stroma cells conferred resistance to anti-leukemic treatment. Moreover, specific sets of proteins with a potential role in survival and the drug response were transferred within these vesicles. Altogether, we found that TNTs are involved in a novel and potent mechanism that participates in leukemia-stroma cross-talk and the stroma-mediated cytoprotection of leukemic cells. Our findings implicate TNT connections as a possible target for therapeutic interventions within the leukemia microenvironment to attenuate stroma-conferred protection.

2022-02-16 | PXD011013 | Pride

Tunneling nanotubes contribute to the stroma-mediated imatinib resistance of leukemic cells DID

2019-11-11 | PXD013504 | Pride

Effects of Carbon Nanotubes Substrates on dendritic cells

Project description:To assess the effect of carbon nanotubes substrated on dendritic cell (DCs) properties, DCs were generated from human monocytes of healthy donors as previously described (Aldinucci A et al, 2010). In particular, isolated monocytes were cultured for 6 days in medium supplemented with GM-CSF (1000U/ml) and IL-4 (1000U/ml), in presence or absence of multi-walled carbon nanotubes (MWCNT); then DCs were activated by 24 hours of incubation with LPS (1ug/ml). RNA extracted from floating and CNT adherent DCs were then used for transcriptional profilingthen used

2015-04-01 | E-MEXP-3560 | biostudies-arrayexpress

RockDove Parental Care

Project description:RockDove Parental Care

| PRJEB28684 | ENA