Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Characterization of genomic and chromatin landscape of RPE-1 WT cells

ABSTRACT: Characterization of genomic and chromatin landscape of RPE-1 WT cells

PROVIDER: PRJNA865654 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR20791476.fastq.gz	Fastqsanger.gz
	SRR20791477.fastq.gz	Fastqsanger.gz
	SRR20791478.fastq.gz	Fastqsanger.gz
	SRR20791479.fastq.gz	Fastqsanger.gz
	SRR20791480.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 17

Similar Datasets

Characterization of genomic and chromatin landscape of RPE-1 WT cells

Project description:Characterization of genomic and chromatin landscape of RPE-1 WT cells

2022-08-03 | GSE210402 | GEO

Characterization of genomic and chromatin landscape of RPE cells

Project description:Characterization of genomic and chromatin landscape of RPE cells

| PRJNA685751 | ENA

Characterization of genomic and chromatin landscape of RPE cells

Project description:We have performed different High-throughput sequencing techniques to characterize the chromatin and 3D genome of RPE-1 cells. Some of the samples are performed with RPE cells that are resistant to taxol.

2020-12-17 | GSE163315 | GEO

RFX7 DNA binding landscape in RPE-1

Project description:Identification of the DNA binding landscape of the transcription factor regulatory factor X 7 (RFX7) in Nutlin-3a and DMSO control treated RPE-1 cells.

2021-06-17 | GSE162159 | GEO

Characterization of hES derived Retinal Pigment Epithelial (RPE). RPE proliferation involves a non-classical Epithelial-Mesenchymal Transition (EMT).

Project description:Retinal Pigment Epithelial (RPE) cells are located behind the retina and are critical for photoreceptor survival. Loss of RPE is associated with several pathogenic conditions such as Age Related Macular Degeneration and Retinitis Pigmentosa. RPE derived from human embryonic stem cells (hESC) offer a potential source for producing these cells for therapy. Here we report the molecular and cellular characterization of RPE differentiated from hESC. hESC derived RPE are capable of proliferation and lose their epithelial characteristics before becoming confluent and re-differentiating back into their typical pigmented, cobblestoned appearance. During the proliferative phase, they adopt a mesenchymal morphology and express mesenchymal markers. Our results demonstrate that this apparent Epithelial-Mesenchymal Transition is not regulated by the classical EMT transcription factors SNAIL and SLUG. Furthermore, it is possible to regulate RPE de-differentiation and re-differentiation by modulating the Wnt and BMP pathway respectively. These findings further our understanding of the genesis and expansion of RPE which is essential for their therapeutic use.

2012-10-24 | E-MTAB-854 | biostudies-arrayexpress

RFX7 DNA binding landscape in RPE-1

Project description:RFX7 DNA binding landscape in RPE-1

| PRJNA680773 | ENA

Characterization of Stem-cell derived Retinal Pigmented Epithelium (RPE)

Project description:To assess the geome-wide similarities between primary fetal retinal pigmented epithelium (RPE) and stem-cell derived RPE, we performed whole genome microarray expression on primary RPE and both embryonic stem cell (ESC) derived RPE and induced pluripotent stem cell (iPSC) derived RPE. We found ES-derived RPE better resembles fetal RPE than iPS-derived RPE. Gene expression was measured in primary fetal RPE, ES-derived RPE, iPS-derived RPE. ES cells and BJ fibroblasts were used as controls.

2010-11-10 | E-GEOD-25143 | biostudies-arrayexpress

RPE Redifferentiation (miRNA)

2013-01-17 | E-MTAB-960 | biostudies-arrayexpress

Single cell RNA transcriptome landscape in mouse RPE layer after CRISPR administration

Project description:To detect whether gene editing will lead to editing specific changes in cell state and microenvironment. We depicted a landscape in mouse RPE layer after CRISPR administration after single cell RNA transcriptome sequencing.

2022-03-01 | GSE182580 | GEO

Characterization of Stem-cell derived Retinal Pigmented Epithelium (RPE)

2010-11-10 | GSE25143 | GEO