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DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon [RNA-seq]

ABSTRACT: DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon [RNA-seq]

PROVIDER: PRJNA867198 | ENA |

REPOSITORIES: ENA

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DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon

Project description:DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon

| PRJNA867383 | ENA

DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon [Array]

Project description:DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon [Array]

| PRJNA867381 | ENA

DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon [Array]

Project description:Genetic variants in the DNMT3A locus have been associated with inflammatory bowel disease (IBD). DNMT3A is part of the epigenetic machinery physiologically involved in DNA methylation. We show that DNMT3A plays a critical role in maintaining intestinal homeostasis and gut barrier function. DNMT3A expression is downregulated in intestinal epithelial cells (IECs) from IBD patients and upon TNF treatment in murine intestinal organoids. Ablation of DNMT3A in Caco-2 cells results in global DNA hypomethylation, which is linked to impaired regenerative capacity, transepithelial resistance and intercellular junction formation. Genetic deletion of Dnmt3a in IECs (Dnmt3aΔIEC) in mice confirms the phenotype of an altered epithelial ultrastructure with shortened apical-junctional complexes, reduced Goblet cell numbers and increased intestinal permeability in the colon in vivo. Dnmt3aΔIEC mice suffer from increased susceptibility to experimental colitis, characterized by reduced epithelial regeneration. These data demonstrate a critical role for DNMT3A in orchestrating intestinal epithelial homeostasis and response to tissue damage and suggest an involvement of impaired epithelial DNMT3A function in the etiology of IBD.

2022-09-21 | GSE210721 | GEO

DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon [RNA-seq]

2022-09-21 | GSE210714 | GEO

The Wilms' tumour 1 transcription factor regulates epigenetic states via DNA methyltransferase 3A

Project description:The Wilms' tumour 1 transcription factor regulates epigenetic states via DNA methyltransferase 3A.

2012-11-05 | GSE39713 | GEO

DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-09-21 | GSE210763 | GEO

The Wilms' tumour 1 transcription factor regulates epigenetic states via DNA methyltransferase 3A

Project description:The Wilms' tumour 1 transcription factor regulates epigenetic states via DNA methyltransferase 3A. The data consists of two Nimblegen promoter/CpG island microarrays hybridized with MCIP DNA immunoprecipitated from either a HEK293-derived cell line expressing a heterologous WT1 cDNA (W210) or a control cell line containing the expression vector (IP100), both hybridized against input DNA.

2012-11-05 | E-GEOD-39713 | biostudies-arrayexpress

Lactobacillus delbrueckii strain:3A | isolate:3A

Project description:Lactobacillus delbrueckii strain:3A | isolate:3A Genome sequencing

| PRJNA1175442 | ENA

Staphylococcus borealis strain:3A | isolate:3A

Project description:Staphylococcus borealis strain:3A | isolate:3A Genome sequencing and assembly

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DNA Methyltransferase 3A Mediates the Sustained Effects of Stress on Synaptic Functions and Behaviors

Project description:DNA Methyltransferase 3A Mediates the Sustained Effects of Stress on Synaptic Functions and Behaviors

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