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Chronic stress dampens Lactobacillus johnsonii-driven suppression on cancer stemness and enhances colorectal tumorigenicity

ABSTRACT: Chronic stress dampens Lactobacillus johnsonii-driven suppression on cancer stemness and enhances colorectal tumorigenicity

PROVIDER: PRJNA868205 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21002172_1.fastq.gz	Fastqsanger.gz
	SRR21002172_2.fastq.gz	Fastqsanger.gz
	SRR21002173_1.fastq.gz	Fastqsanger.gz
	SRR21002173_2.fastq.gz	Fastqsanger.gz
	SRR21002174_1.fastq.gz	Fastqsanger.gz

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Chronic stress dampens Lactobacillus johnsonii-driven suppression on cancer stemness and enhances colorectal tumorigenicity

Project description:More than one-half of all colorectal cancer cases and deaths are due to modifiable risk factors, while psychological stress stands out as an important factor with mechanism unclear. Polymorphic microbiomes have pivotal roles in CRC. We therefore explored the impact of chronic stress on CRC, and the involvement of gut microbiome and its metabolites in this process.

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Lactobacillus johnsonii NCC comparative genomics with L. iatae

Project description:Whole genome DNA microarray designed for the probiotic L. johnsonii strain NCC533 was used for comparative genomic hybridization (CGH) of L. johnsonii ATCC 33200T, L. johnsonii BL261, L. gasseri ATCC 33323T and L. iatae BL263 (CECT 7394T). In these experiments, the fluorescence ratio distributions obtained with L. iatae and L. gasseri showed characteristic inter-species profiles. The percentage of conserved L. johnsonii NCC533 genes was about 83% in the L. johnsonii strains comparisons and decreased to 51% and 47% for L. iatae and L. gasseri, respectively. These results confirmed the separate status of L. iatae from L. johnsonii at the level of species, and also that it is closer to L. johnsonii than L. gasseri.

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High-fat diet activated fatty acid oxidation mediates intestinal stemness and tumorigenicity

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