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Quiescence Enables Unrestricted Cell Fate in Naive Embryonic Stem Cells

ABSTRACT: Quiescence Enables Unrestricted Cell Fate in Naive Embryonic Stem Cells

PROVIDER: PRJNA868309 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21003468_1.fastq.gz	Fastqsanger.gz
	SRR21003468_2.fastq.gz	Fastqsanger.gz
	SRR21003469_1.fastq.gz	Fastqsanger.gz
	SRR21003469_2.fastq.gz	Fastqsanger.gz
	SRR21003470_1.fastq.gz	Fastqsanger.gz

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Quiescence Enables Unrestricted Cell Fate in Naive Embryonic Stem Cells

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Quiescence Enables Unrestricted Cell Fate in Naive Embryonic Stem Cells

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Quiescence Enables Unrestricted Cell Fate in Naive Embryonic Stem Cells

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Quiescence Enables Unrestricted Cell Fate in Naive Embryonic Stem Cells

Project description:This project will include 42 datasets (24 RNA-seq datasets, 8 CUT&RUN datasets, 4 ATAC-seq datasets, and 6 CRISPR target bisulfite-seq datasets), generated from illumine Hi-seq sequencer to investigate the stem cell quiescence in mouse embryonic stem cells.

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Quiescence Enables Unrestricted Cell Fate in Naive Embryonic Stem Cells

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Quiescence Enables Unrestricted Cell Fate in Naive Embryonic Stem Cells

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Quiescence Enables Unrestricted Cell Fate in Naive Embryonic Stem Cells

Project description:This project will include 42 datasets (24 RNA-seq datasets, 8 CUT&RUN datasets, 4 ATAC-seq datasets and 6 CRISPR target bisulfite-seq datasets), generated from illumine Hi-seq sequencer to investigate the stem cell quiescence in mouse embryonic stem cells.

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Quiescence Enables Unrestricted Cell Fate in Naive Embryonic Stem Cells

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Polycomb Repressive Complex 2 Restricts Human Naive Pluripotent Stem Cell to Trophoblast Fate Induction

Project description:Human naive pluripotent stem cells have unrestricted lineage potential. Underpinning this property, naive cells are thought to lack chromatin-based lineage barriers. However, this assumption has not been tested. Here, we apply multi-omics to comprehensively define the chromatin-associated proteome, histone post-translational modifications and transcriptome of human naive and primed pluripotent stem cells. Integrating the chromatin-bound proteome and histone modification data sets reveals differences in the relative abundance and activities of distinct chromatin modules, identifying a strong enrichment of Polycomb Repressive Complex 2 (PRC2)-associated H3K27me3 in naive pluripotent stem cell chromatin. Single-cell approaches and human blastoid models reveal that PRC2 activity acts as a chromatin barrier restricting the differentiation of naive cells towards the trophoblast lineage, and inhibiting PRC2 promotes trophoblast fate induction and cavity formation. Our results establish that human naive pluripotent stem cells are not epigenetically unrestricted, but instead possess chromatin mechanisms that oppose the induction of alternative cell fates.

2022-05-06 | PXD028111 | Pride

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