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Hematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic hemogenic endothelium [RNA-seq]

ABSTRACT: Hematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic hemogenic endothelium [RNA-seq]

PROVIDER: PRJNA868349 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21006662.fastq.gz	Fastqsanger.gz
	SRR21006663.fastq.gz	Fastqsanger.gz
	SRR21006664.fastq.gz	Fastqsanger.gz
	SRR21006665.fastq.gz	Fastqsanger.gz
	SRR21006666.fastq.gz	Fastqsanger.gz

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Hematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic hemogenic endothelium.

Project description:Hematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic hemogenic endothelium.

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Hematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic hemogenic endothelium [scRNA-seq]

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Differential Ezh1/2 regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium

Project description:Across species, hematopoietic stem and progenitor cells (HSPCs) arise during embryogenesis from a specialized arterial population, termed hemogenic endothelium. Here, we describe a mechanistic role for the epigenetic regulator, Enhancer of zeste homolog-1 (Ezh1) in vertebrate HSPC production via regulation of hemogenic commitment. Loss of ezh1 in zebrafish embryos favored acquisition of hemogenic (gata2b) and HSPC (runx1) fate at the expense of the arterial program (ephrinb2a, dll4). In contrast, ezh1 overexpression blocked hematopoietic progression via maintenance of arterial gene expression. The related polycomb group subunit, Ezh2, functioned in a non-redundant, sequential manner, whereby inhibition had no impact on arterial identity, but was capable of blocking ezh1-knockdown associated HSPC expansion. Single-cell RNA-seq across ezh1 genotypes revealed a dropout of ezh1+/- cells among arterial endothelium associated with positive regulation of gene transcription. Exploitation of Ezh1/2 modulation has potential functional relevance for improving in vitro HSPC differentiation from induced pluripotent stem cell sources.

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Project description:The differentiation of human embryonic stem cells to hematopoietic lineages initiates with the specification of hemogenic endothelium, a transient specialized endothelial precursor of all blood cells.Unfortunately, absence of hemogenic endothelium-specific markers as well as lack of consensus in the timing of hemogenic potential analysis and methodologies used to study the hematopoietic potential of this precursor prevents reaching clear and definite conclusions. Here, we demonstrate that the hemogenic potential of the endothelium precursor population sharply decline over the course of the differentiation process. Poly(A) RNA-sequencing on CD31+CD144+ population at day 6, day 8 and day 10 of EB diffferentiation with or without the addition of cytokines. Comparasion with hematopoietic committed population CD31+CD144- from day 10 of EB differentiation.

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HoxA3 is an apical regulator of hemogenic endothelium

Project description:This SuperSeries is composed of the following subset Series: GSE25079: Epistasis analysis of Runx1 and Gata1 over HoxA3 in hemogenic endothelium GSE25080: Genes regulated by HoxA3 in endothelial and hematopoietic progenitors Refer to individual Series

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Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity

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Hematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic hemogenic endothelium.

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Hematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic hemogenic endothelium [scRNA-seq]

Project description:Investigate the role of miR128 in the EHT process and the formation of nHSPCs