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Multipartite super-enhancers function in an orientation-dependent manner [Capture-C]

ABSTRACT: Multipartite super-enhancers function in an orientation-dependent manner [Capture-C]

PROVIDER: PRJNA869660 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21051726_1.fastq.gz	Fastqsanger.gz
	SRR21051726_2.fastq.gz	Fastqsanger.gz
	SRR21051727_1.fastq.gz	Fastqsanger.gz
	SRR21051727_2.fastq.gz	Fastqsanger.gz
	SRR21051728_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

Multipartite super-enhancers function in an orientation-dependent manner

Project description:Multipartite super-enhancers function in an orientation-dependent manner

| PRJNA869663 | ENA

Multipartite super-enhancers function in an orientation-dependent manner [Capture-C]

Project description:Transcriptional enhancers regulate gene expression in a developmental-stage and cell-specific manner. They were originally defined as individual regulatory elements that activate expression regardless of distance and orientation to their cognate genes. Genome-wide studies have shown that the mammalian enhancer landscape is much more complex, with different classes of individual enhancers and clusters of enhancer-like elements combining in additive, synergistic and redundant manners, possibly acting as single, integrated regulatory elements. These so-called super-enhancers are largely defined as clusters of enhancer-like elements which recruit particularly high levels of Mediator and often drive high levels of expression of key lineage-specific genes. Here, we analysed 78 erythroid-specific super-enhancers and showed that, as units, they preferentially interact in a directional manner, to drive expression of their cognate genes. Using the well characterised a-globin super-enhancer, we show that inverting this entire structure severely downregulates a-globin expression and activates flanking genes 5’ of the super-enhancer. Our detailed genetic dissection of the a-globin locus clearly attributes the cluster’s functional directionality to its sequence orientation, demonstrating that, unlike regular enhancers, super-enhancers act in an orientation-dependent manner. Together, these findings identify a novel emergent property of super-enhancers and revise current models by which enhancers are thought to contact and activate their cognate genes.

2022-08-18 | GSE211233 | GEO

Multipartite super-enhancers function in an orientation-dependent manner [ChIP-Seq]

Project description:Multipartite super-enhancers function in an orientation-dependent manner [ChIP-Seq]

| PRJNA869664 | ENA

Multipartite super-enhancers function in an orientation-dependent manner [ATAC-Seq]

Project description:Multipartite super-enhancers function in an orientation-dependent manner [ATAC-Seq]

| PRJNA869661 | ENA

Multipartite super-enhancers function in an orientation-dependent manner [RNA-Seq]

Project description:Multipartite super-enhancers function in an orientation-dependent manner [RNA-Seq]

| PRJNA869667 | ENA

Multipartite super-enhancers function in an orientation-dependent manner [RNA-Seq]

2022-08-18 | GSE211237 | GEO

Multipartite super-enhancers function in an orientation-dependent manner [ChIP-Seq]

2022-08-18 | GSE211236 | GEO

Multipartite super-enhancers function in an orientation-dependent manner [ATAC-Seq]

2022-08-18 | GSE211232 | GEO

Multipartite super-enhancers function in an orientation-dependent manner

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-18 | GSE211238 | GEO

Centromere interactions promote the maintenance of the multipartite genome in Agrobacterium tumefaciens

Project description:Many pathogens and symbionts contain multipartite genomes, but how they are stably maintained is poorly understood. The plant pathogen, Agrobacterium tumefaciens, contains four replicons. Recent work indicates that their replication origins cluster at cell poles in a manner that depends on their ParB-family centromeric proteins. Here, we provide evidence that centromeric clustering is mediated by interactions between these centromeric proteins. We further show that the disruption of centromere clustering results in the loss of replicons. Our data establish the role of centromeric clustering in multipartite genome maintenance.

2022-04-28 | GSE196319 | GEO

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