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Effect of depletion of METTL3 on gene expression of A549 cells

ABSTRACT: Effect of depletion of METTL3 on gene expression of A549 cells

PROVIDER: PRJNA870291 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21101394_1.fastq.gz	Fastqsanger.gz
	SRR21101394_2.fastq.gz	Fastqsanger.gz
	SRR21101395_1.fastq.gz	Fastqsanger.gz
	SRR21101395_2.fastq.gz	Fastqsanger.gz
	SRR21101396_1.fastq.gz	Fastqsanger.gz

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Effect of depletion of METTL3 on gene expression of A549 cells

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Project description:The RNA modification N6-methyladenosine (m6A) regulates gene expression through various transcript-specific effects. The overall goal of these experiments was to determine the effects of the m6A methyltransferase complex proteins METTL3 and METTL14 on the expression of interferon stimulated genes. First, we depleted METTL3 and METTL14 in Huh7 cells using siRNAs and treated with Mock or IFN-β to analyze the regulatory effects of METTL3/14 on interferon-stimulated genes' transcript abundance. We then used Ribo-seq following METTL3/14 siRNA depletion and IFN treatment to quantify its effect on the translation of ISGs and other genes. Overall, we found that METTL3/14 exerts transcript-specific regulatory effects on a subset of interferon-stimulated genes. Overall, METTL3/14 appeared to enhance the translation of a subset of interferon-stimulated genes. We characterized the molecular effects of METTL3/14 and m6A on certain ISGs and determined that m6A augments the antiviral effects of the interferon response.

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