Project description:Integrative proteo-trnascriptomics analysis of MDR abd drug sensitive E. coli strains isolated from river Yamuna, Delhi, India to identify novel drug targets against Multi drug Resistant E. coli
2025-02-10 | PXD048998 | Pride
Project description:Compensatory evolution of multi-drug resistant Escherichia coli
Project description:Background: This study aimed to explore potential tobramycin-resistant mutagenesis of Escherichia coli (E. coli) strains after spaceflight. Methods: A spaceflight-induced mutagenesis of multi-drug resistant E.coli strain (T1_13) on the outer space for 64 days (ST5), and a ground laboratory with the same conditions (GT5) were conducted. Both whole-genome sequencing and RNA-sequencing were performed. Results: A total of 75 SNPs and 20 InDels were found to be associated with the resistance mechanism. Compared to T1_13, 1242 genes were differentially expressed in more than 20 of 38 tobramycin-resistant E. coli isolates while not in GT5. Function annotation of these SNPs/InDels related genes and differentially expressed genes was performed. Conclusion: This study provided clues for potential tobramycin-resistant spaceflight-induced mutagenesis of E. coli.
2019-12-13 | GSE123795 | GEO
Project description:Genotyping and Molecular characterization of ESBL-producing and Carbapenem-resistant Escherichia coli and Enterobacter hormaechei isolated from sick cats in Lebanon
| PRJNA1028851 | ENA
Project description:Molecular characterization of the multi-drug resistant Myroides odoratimimus isolates
