Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tobacco Smoke Exacerbates Filifactor alocis Pathogenicity

ABSTRACT: Tobacco Smoke Exacerbates Filifactor alocis Pathogenicity

PROVIDER: PRJNA870570 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Tobacco Smoke Exacerbates Filifactor alocis Pathogenicity

Project description:RNA sequencing was used to identify genes up- and down-regulated when Fa was grown in cigarette smoke media

2023-03-08 | GSE211505 | GEO

Filifactor alocis

Project description:Filifactor alocis overview

| PRJNA37455 | ENA

Transcriptome analysis of Filifactor alocis in co-culture with Porphyromonas gingivalis

Project description:We use high through put RNA sequenceing technology to study the genome-wide expression profile in an oral pathogen Filifactor alocis when co-cultured with another key-stone oral pathogen Porphyromonas gingivalis under anaerobic conditions and oxidative stress conditions.

2021-08-13 | GSE181879 | GEO

Proteomic analysis of Filifactor alocis type and clinically isolated strains

Project description:Filifactor alocis is a Gram-positive asaccharolytic, obligate anaerobic rod of the phylum Firmicutes, strongly associated with periodontitis. In this study, we performed the whole proteomic analysis of an F. alocis type strain (ATCC 35896; CCUG 47790), as well as nine clinically isolated strains at the Clinical Oral Microbiology Laboratory, Umeå University, for identification and deeper characterization of this species. Label-free quantification was used to compare the proteomic differences between different strains.

2022-06-09 | PXD026971 | Pride

Global changes in human neutrophil transcriptome profile during Filifactor alocis challenge

Project description:Periodontitis is a multifactorial chronic inflammatory infectious disease with a high prevalence in the adult population in the USA. Until recently, research into periodontitis focused primarily on putative pathogens such as Porphyromonas gingivalis. However, a reappraisal of microbial etiology has marked a turning point in the field due to the development of culture-independent techniques that allow the identification of bacterial species directly from nucleic acids. Filifactor alocis, a Gram positive anaerobic oral bacterium, has emerged as an important periodontal pathogen. Neutrophils are recruited in high numbers to the gingival tissue, where they are linked with protection against periodontal disease. However, periodontal pathogens evolved different strategies to resist neutrophil microbicidal mechanisms while propagating inflammation, which affords a source of nutrients. The goal of this study was to determine the global changes in human neutrophil gene expression induced by F. alocis challenge. RNA-sequencing analysis shows that F. alocis-challenge alters human neutrophil transcriptome including expression of genes associated with regulation of Toll-Like Receptor signaling pathway, MAPK signaling pathway, apoptosis, cytokines and chemokines, among other neutrophil effector functions.

2020-04-06 | GSE137351 | GEO

Transcriptome analyses of Filifactor alocis ATCC35896 and Porphyromonas gingivalis W83 in mono-culture as compared to co-culture under hydrogen peroxide stress conditions

Project description:Oal anaerobic bacteria have to face constant oxidative stress in order to survive in the inflammatory environment of the periodontal pocket. In this study, we analyzed the transcriptome profiles of P. gingivalis and Filifactor in monoculture as compared to P. gingivalis+F.alocis coculture under H2O2 stress condtions, to analyze the genes responsible for enhanced survival of P. gingivalis in presence of F. alocis under oxidative-stress conditions.

2023-09-01 | GSE241660 | GEO

Global changes in human neutrophil transcriptome profile during Filifactor alocis challenge

Project description:Global changes in human neutrophil transcriptome profile during Filifactor alocis challenge

| PRJNA565218 | ENA

Transcriptome analysis of Filifactor alocis in co-culture with Porphyromonas gingivalis

Project description:Transcriptome analysis of Filifactor alocis in co-culture with Porphyromonas gingivalis

| PRJNA753797 | ENA

Tobacco smoke exposure exacerbates silica-induced pulmonary toxicity in rats

Project description:Tobacco smoke exposure exacerbates silica-induced pulmonary toxicity in rats

| PRJNA564098 | ENA

Tobacco smoke exposure exacerbates silica-induced pulmonary toxicity in rats

Project description:Previous studies have shown that smoking induces oxidative stress and inflammation, known factors that coincide with the development and progression of silicosis. Nevertheless, the precise role of cigarette smoke exposure in silicosis and the underlying mechanisms are not clearly understood. Therefore, the objective of the present study was to determine the effect of smoking, if any, on silica-induced pulmonary response and the underlying mechanisms. Pulmonary toxicity and lung gene expression profiles were determined in male Fischer 344 rats exposed to air, crystalline silica, cigarette smoke or cigarette smoke plus crystalline silica. Silica exposure resulted in significant pulmonary toxicity which was further exacerbated by cigarette smoke exposure in the rats. Significant differences in the gene expression profiles were detected in the lungs of the rats exposed to cigarette smoke, silica or a combination of both compared with the control rats.

2020-11-01 | GSE136945 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data