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Transcriptional profile of Cas9+HoxB8 neutrophil progenitors at day 0 and day 2 after withdrawal of estrogen

ABSTRACT: Transcriptional profile of Cas9+HoxB8 neutrophil progenitors at day 0 and day 2 after withdrawal of estrogen

PROVIDER: PRJNA871764 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21147620_1.fastq.gz	Fastqsanger.gz
	SRR21147620_2.fastq.gz	Fastqsanger.gz
	SRR21147621_1.fastq.gz	Fastqsanger.gz
	SRR21147621_2.fastq.gz	Fastqsanger.gz
	SRR21147622_1.fastq.gz	Fastqsanger.gz

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Transcriptional profile of Cas9+HoxB8 neutrophil progenitors at day 0 and day 2 after withdrawal of estrogen

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Oncogenic HOXB8 is driven by MYC-regulated super-enhancer and potentiates colorectal cancer invasiveness via BACH1 [RNA-seq]

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Project description:Examination of open chromatin regions between clonal neutrophil progenitor populations. Conditionally immortalized CD45.1 naive paired granulocyte-monocyte progenitors (GMPs) and their mature neutrophil counterpart were profiled in an in vitro cell system. We identified 29,966 differentially accessible regions (DARs) between GMPs and neutrophils, from a total of 74,009 consensus peaks of chromatin accessibility. There is some correlation of open chromatin between GMP and mature neutrophil clones.

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