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High-throughput sequencing in SLE patients PBMC

ABSTRACT: High-throughput sequencing in SLE patients PBMC

PROVIDER: PRJNA871765 | ENA |

REPOSITORIES: ENA

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High-throughput sequencing in SLE patients PBMC

Project description:High-throughput sequencing was performed on the PBMCs from SLE patients and healthy control. The purpose of the current study is to identify new genes and pathways of interest involved in the pathogenesis of SLE.

2023-01-13 | GSE211700 | GEO

LC-MS of PBMC in SLE and healthy control

Project description:Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease that displays a significant gender difference in terms of incidence and severity. However, the underlying mechanisms accounting for sexual dimorphism remain unclear. To reveal the heterogeneity in the pathogenesis of SLE between male and female patients. PBMC were collected from 15 patients with SLE (7 males, 8 females) and 15 age-matched healthy controls (7 males, 8 females) for proteomic analysis. Enrichment analysis of proteomic data revealed that type I interferon signaling and neutrophil activation networks mapped to both male and female SLE, while male SLE has a higher level of neutrophil activation compared with female SLE. Our findings define gender heterogeneity in the pathogenesis of SLE and may facilitate the development of gender-specific treatments.

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RNA-seq of peripheral blood mononuclear cell (PBMC) derived from normal healthy donors and systemic lupus erythematosus (SLE) patients

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2020-08-14 | E-MTAB-7145 | biostudies-arrayexpress

High-throughput sequencing of plasma microRNA in elderly men fed a high protein diet in relation to the PBMC transcriptome: A 10 week randomized controlled trial

Project description:High-throughput sequencing of plasma microRNA in elderly men fed a high protein diet in relation to the PBMC transcriptome: A 10 week randomized controlled trial

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High-throughput combinatorial indexing enables scalable single-cell chromatin accessibility profiling [PBMC]

Project description:High-throughput combinatorial indexing enables scalable single-cell chromatin accessibility profiling [PBMC]

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SLE PBMC RNA-seq

Project description:RNA sequencing of systemic lupus erythematosus (SLE) and healthy PBMCs to measure transcriptional changes in gene and endogenous retrovirus expression

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Next Generation Sequencing Facilitates Quantitative Analysis of Health donors and SLE patients' PBMC Transcriptomes

Project description:Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare SLE patients to Health donors PBMCs-derived transcriptome profiling (RNA-seq) to microarray and quantitative reverse transcription polymerase chain reaction (qRT–PCR) methods and to discovery the potential pathway which can be used as a therapeutic target.

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Differential expression Profiles of microRNAs in PBMC specimen from tuberculosis patients and normal volunteers

Project description:Purpose: To investigate the role and mechanism of microRNAs in tuberculosis. Methods: microRNAs sequencing were performed to screen differential expressed microRNAs in PBMC specimen between tuberculosis patients and normal volunteers. Results: A total of 1560 distinct microRNAs were identified in these samples, and 788 of these microRNAs were upregulated and 772 microRNAs were downregulated. Overall design: Tuberculosis differential expression Profiles of microRNAs in PBMC were generated by high throughput sequencing, using Illumina Hiseq2000/2500.

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miRNAs expression in kidney tissues of systemic lupus erythematosus (SLE) individuals

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