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Analysis of the consequences of the constitutive loss of Prdm12 in developing trigeminal ganglia

ABSTRACT: Analysis of the consequences of the constitutive loss of Prdm12 in developing trigeminal ganglia

PROVIDER: PRJNA872923 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21203019.fastq.gz	Fastqsanger.gz
	SRR21203020.fastq.gz	Fastqsanger.gz
	SRR21203021.fastq.gz	Fastqsanger.gz
	SRR21203022.fastq.gz	Fastqsanger.gz
	SRR21203023.fastq.gz	Fastqsanger.gz

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Analysis of the consequences of the constitutive loss of Prdm12 in developing trigeminal ganglia

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Project description:SARS-CoV-2, the virus responsible for COVID-19, infects both human airway epithelial cells and trigeminal ganglia. We assessed the consequences of SARS-CoV-2 infection on gene expression in Calu-3 cells and in primary Mus musculus trigeminal ganglia cells (mmTG). Here, we provide datasets that include raw reads and mapped reads for the following: 1) mock infected mmTG 48 hrs post infection; 2) SARS-CoV-2 infected mmTG 48 hrs post infection; 3) mock infected Calu-3 cells 24 hrs post infection; 4) SARS-CoV-2 infected Calu-3 cells 24 hrs post infection; 5) mock infected Calu-3 cells 48 hrs post infection; 6) SARS-CoV-2 infected Calu-3 cells 48 hrs post infection.

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Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation.

Project description:Prdm12 is a key transcription factor in nociceptor neurogenesis. Mutations of Prdm12 cause Congenital Insensitivity to Pain (CIP) due to failure of nociceptor development. However, precisely how deletion of Prdm12 during development or adulthood affects nociception is unknown. Here, we employ tissue- and temporal-specific knockout mouse models to test the function of Prdm12 during development and in adulthood. We find that constitutive loss of Prdm12 causes deficiencies in proliferation during sensory neurogenesis. We also demonstrate that conditional knockout from dorsal root ganglia (DRGs) during embryogenesis causes defects in nociception. In contrast, we find that in adult DRGs, Prdm12 is dispensable for most pain sensation and injury-induced hypersensitivity. Using transcriptomic analysis, we found mostly unique changes in adult Prdm12 knockout DRGs compared to embryonic knockout, and that PRDM12 is likely a transcriptional activator in the adult. Overall, we find that the function of PRDM12 changes over developmental time.

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