Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Coxiella burnetii Nine mile phase II sequencing

PROVIDER: PRJNA872953 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR21197703_1.fastq.gz	Fastqsanger.gz
	SRR21197703_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 3 of 3

Similar Datasets

Coxiella Burnetii - Identification of potentially involved proteins in levofloxacin resistance mechanisms in Coxiella burnetii

Project description:Coxiella Burnetii Nine Mile vs Nine Mile resistant to levofloxacine

2012-07-20 | PRD000262 | Pride

Coxiella Burnetii

Project description:Coxiella Burnetii nine mile phase II Genome sequencing and assembly

| PRJNA514426 | ENA

Comparative genomic hybridization of 25 Coxiella burnetii isolates relative to the Nine Mile (RSA493) reference isolate

Project description:Analysis of genetic diversity of 25 Coxiella burnetii isolates with relative to the Nine Mile (RSA493) reference isolate.

2006-10-30 | E-TABM-35 | biostudies-arrayexpress

Project description:Genome sequences of Coxiella burnetii Nine Mile phase I and II

| PRJNA352565 | ENA

Early response of Coxiella burnetii to temperature stress

2011-01-01 | GSE21778 | GEO

Macrophage infectivity potentiator protein, a peptidyl prolyl cis/trans isomerase, essential for Coxiella burnetii growth and pathogenesis

Project description:Coxiella burnetii is a Gram-negative intracellular pathogen that causes the debilitating disease Q fever, which affects both animals and humans. The only available vaccine, Q-Vax, is effective but has a high risk of severe adverse reactions, limiting its use as a countermeasure to contain outbreaks. Therefore, it is essential to identify new drug targets to treat this infection. Macrophage infectivity potentiator (Mip) proteins catalyze the folding of proline-containing proteins through their peptidyl prolyl cis-trans isomerase (PPIase) activity and have been shown to play an important role in the virulence of several pathogenic bacteria but to date its role in C. burnetii pathogenesis has not been investigated. This study demonstrates that CbMip is likely to be an essential protein in C. burnetii. Pipecolic acid derived compounds, SF235 and AN296 demonstrate inhibitory activities against CbMip and these compounds were found to significantly inhibit intracellular replication of C. burnetii in both HeLa and THP-1 cells. Furthermore, SF235 and AN296 were also found to exhibit antibiotic properties against both the virulent (Phase I) and avirulent (Phase II) forms of C. burnetii Nine Mile Strain RSA439 in axenic culture with comparative proteomic demonstrating selective alterations in response to these agents. This study also showed that exposure of C. burnetii to Mip inhibitors resulted in increased sensitivity to oxidative stress. Furthermore, compounds SF235 and AN296 demonstrated protective activity in vivo and significantly improved the survival of Galleria mellonella infected with C. burnetii. These results suggest that unlike in other bacteria, Mip in C. burnetii is required for growth and replication and that inhibitors against CbMip offer potential as novel therapeutics against C. burnetii.

2023-06-15 | PXD036679 | Pride

Early response of Coxiella burnetii to temperature stress

Project description:Transcriptional profiling of Coxiella burnetii phase I (RSA 493) submitting either to Cold and Heat shock comparing to control untreated Coxiella burnetii phase I (RSA 493) grown at 35Â°C. Four experiments : Cold shock 30 min Vs 35Â°C; Cold shock 60 min Vs 35Â°C; Heat shock 30 min Vs 35Â°C; Heat shock 60 min Vs 35Â°C 3 biological replicates, independently grown and harvested. Four replicate per array.

2011-01-01 | E-GEOD-21778 | biostudies-arrayexpress

Project description:Genome Sequence of Coxiella burnetii Nine Mile II, Clone 4, delta_cbu0533 Mutant Strain, An Alternative for Safer Laboratory Use

| PRJNA1085302 | ENA

Genotyping of Coxiella burnetii strains collection

Project description:Genotyping based on genomic comparative hybridization of different isolates of coxiella burnetii compared to NMI reference strain

2011-12-31 | GSE31543 | GEO

Human THP-1 Cells: Uninfected vs. Coxiella burnetii NMII infected compared to Uninfected with Chloramphenicol vs. Coxiella burnetii NMII infected with Chloramphenicol

Project description:A comparison was made between the THP-1(Human monocytic leukemia cells - TIB-202; ATCC) transcriptional responses of; (i) uninfected versus Coxiella burnetii NMII infected and (ii) uninfected versus Coxiella burnetii NMII infected THP-1 cells transiently treated with bacteriostatic levels (10μg/ml) of chloramphenicol (CAM). Briefly, infections were initiated and cultured in parallel with uninfected cells. At 48 hours post infection (hpi), media containing CAM (10μg/ml) was added to one set of cells (uninfected and infected THP-1 cells) and culturing was continued. The other set of cells were mock treated with normal media. Total RNA was isolated at 72 hpi from all conditions. Microarrays were performed for both condition sets and the results from each of the two microarrays were compared to define the host genes modulated by de novo C. burnetii NMII protein synthesis.

2010-10-01 | GSE23665 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data