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Hepatic Stellate Cells inhibition induced by YAP deletion

ABSTRACT: Hepatic Stellate Cells inhibition induced by YAP deletion

PROVIDER: PRJNA873694 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21201623_1.fastq.gz	Fastqsanger.gz
	SRR21201623_2.fastq.gz	Fastqsanger.gz
	SRR21201624_1.fastq.gz	Fastqsanger.gz
	SRR21201624_2.fastq.gz	Fastqsanger.gz
	SRR21201625_1.fastq.gz	Fastqsanger.gz

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Hepatic Stellate Cells inhibition induced by YAP deletion

Project description:Gene expression by bulk RNAseq in isolated mouse Hepatic Stellate Cells (HSC) YAP ko compared to HSC YAP floxed (wt).

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The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

Project description:We identified the Hippo pathway and its effector YAP as a key pathway that controls stellate cell activation. YAP is a transcriptional co-activator and we found that it drives the earliest changes in gene expression during stellate cell activation. Activation of stellate cells in vivo by CCl4 or activation in vitro caused rapid activation of YAP as revealed by its nuclear translocation and the induction of YAP target genes.

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Hepatic Stellate Cells activation induced by Lhx2 deletion

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Consequences of beta-PDGFR deletion on hepatic stellate cells during hepatic regeneration

Project description:Purpose: The goal of this study was to determine biological consequences during liver regeneration following partial hepatectomy in mice by next-generation sequencing. A particular interest was to compare mice with either a floxed b-PDGFR allele to mice that harbored a deletion of b-PDGFR in hepatic stellate cells (HSCs), by crossing b-PDGFR fl/fl mice with transgenic GFAP-Cre mice. Methods: b-PDGFR fl/fl mice or mice with a HSC-specific deletion of b-PDGFR underwent either sham operation or 70% partial hepatectomy. Following 72 hours, livers were collected and total RNA was extracted using tizol, followed by a purification using Quiagen spin columns including an on-column DNAse digestion step. Conclusion: Our study represents a detailed analysis of hepatic transcriptome, with biologic replicates, generated by RNA-seq technology of livers following sham operation or partial hepatectomy in b-PDGFR fl/fl mice or b-PDGFRfl/fl/GRAP-Cre mice. Whole liver mRNA profiles of sham operated livers or livers collected 72hours after partial hepatectomy of beta-PDGFR fl/fl and beta-PDGFR fl/fl/GFAP-Cre (creating a hepatic stellate cell-specific deletion of b-PDGFR) mice were generated by deep sequencing, in duplicate, using Illumina HiSeq2000.

2013-11-08 | E-GEOD-52234 | biostudies-arrayexpress

Hepatic Stellate Cells activation induced by Lhx2 deletion

Project description:Gene expression in isolated mouse Hepatic Stellate Cells (HSC) Lhx2 ko compared to HSC Lhx2 floxed.

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Effect of SHP2 inhibition on hepatic stellate cell transcriptome.

Project description:Effect of SHP2 inhibition on hepatic stellate cell transcriptome.

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The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

Project description:The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

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Early Mouse Hepatic Stellate Cell Activation

Project description:Early during culture of primary mouse HSCs gene expression changes. These expression alterations can be affected by treating cells with histone deacetylase inhibitor, valproic acid Primary mouse Hepatic stellate cells were cultured for short periods of time (4-16-64h) in presence or absence of valproic acid. Gene expression analysis (mouse Gene 1.0 ST arrays according to manufacturerM-bM-^@M-^Ys manual 701880Rev4 (Affymetrix, Santa Clara, CA)), in vitro stellate cell activation and inhibition of the activation by valproic acid treatment.

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Deactivation of Hepatic Stellate Cells during Liver Fibrosis Resolution in Mice

Project description:Gene expression of mouse hepatic stellate cells was characterized under the following conditions: Quiescent (isolated from normal mouse liver) and reverted (isolated from mouse liver treated with 4 injections of carbontetrachloride followed by 45 day rest period) Affymetrix Mouse 1.0ST gene expression measurements were used to characterize the transcriptomic basis in quiescent hepatic stellate cells, isolated from normal liver, and reverted hepatic stellate cells, isolated from liver treated with 4 injections of CCl4 followed by a 45 day rest period. Gene expression of mouse hepatic stellate cells was characterized under the following conditions: A. Quiescent control hepatic stellate cells (n=4). B. Reverted hepatic stellate cells (n=4).

2014-05-05 | E-GEOD-38648 | biostudies-arrayexpress

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