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Identification and analysis of microRNA editing events in recurrent bladder cancer based on RNA sequencing: microRNA editing level is a potential novel biomarker

ABSTRACT: Identification and analysis of microRNA editing events in recurrent bladder cancer based on RNA sequencing: microRNA editing level is a potential novel biomarker

PROVIDER: PRJNA874087 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21224257_1.fastq.gz	Fastqsanger.gz
	SRR21224257_2.fastq.gz	Fastqsanger.gz
	SRR21224258_1.fastq.gz	Fastqsanger.gz
	SRR21224258_2.fastq.gz	Fastqsanger.gz
	SRR21224259_1.fastq.gz	Fastqsanger.gz

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Identification and analysis of microRNA editing events in recurrent bladder cancer based on RNA sequencing: microRNA editing level is a potential novel biomarker

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Project description:RNA editing is a post-transcriptional modification, which can provide tissue-specific functions not encoded in DNA. Adenosine-to-inosine is the predominant editing event and, along with cytosine-to-uracil changes, constitutes canonical editing. The rest is non-canonical editing. In this study, we have analysed non-canonical editing of microRNAs in the human brain. We have performed massively parallel small RNA sequencing of frontal cortex (FC) and corpus callosum (CC) pairs from nine normal individuals (post-mortem). We found 113 and 90 unique non-canonical editing events in FC and CC samples, respectively. More than 70% of events were in the miRNA seed sequence-implicating an altered set of target mRNAs and possibly resulting in a functional consequence. Up to 15% of these events were recurring and found in at least three samples, also supporting the biological relevance of such variations. Two specific sequence variations, C-to-A and G-to-U, accounted for over 80% of non-canonical miRNA editing events-and revealed preferred sequence motifs. Our study is one of the first reporting non-canonical editing in miRNAs in the human brain. Our results implicate miRNA non-canonical editing as one of the contributing factors towards transcriptomic diversity in the human brain.

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