Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Stress induced accelerated aging in mouse eye [ChIP-seq]

ABSTRACT: Stress induced accelerated aging in mouse eye [ChIP-seq]

PROVIDER: PRJNA874433 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR21283990_1.fastq.gz	Fastqsanger.gz
	SRR21283990_2.fastq.gz	Fastqsanger.gz
	SRR21283991_1.fastq.gz	Fastqsanger.gz
	SRR21283991_2.fastq.gz	Fastqsanger.gz
	SRR21283992_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Stress induced accelerated aging in mouse eye

Project description:Stress induced accelerated aging in mouse eye

| PRJNA874435 | ENA

Stress induced accelerated aging in mouse eye [ATAC-seq]

Project description:Stress induced accelerated aging in mouse eye [ATAC-seq]

| PRJNA874436 | ENA

Stress induced accelerated aging in mouse eye [RNA-seq]

Project description:Stress induced accelerated aging in mouse eye [RNA-seq]

| PRJNA874434 | ENA

Stress induced accelerated aging in mouse eye [ChIP-seq]

Project description:Aging, a universal process that affects all cells in an organism, is a major risk factor for a group of neuropathies called glaucoma, where elevated intraocular pressure is one of the known stresses affecting the tissue. Our understanding of molecular impact of aging on response to stress in retina is very limited, therefore we developed a new mouse model to approach this question experimentally. Here we show that susceptibility to response to stress increases with age and is primed on chromatin level. We demonstrate that program activated by stress caused by ocular hypertension is similar to natural aging and involves activation of inflammation and senescence. Finally, we show that multiple instances of pressure elevation cause accelerated aging of young retina as measured on transcriptional and epigenetic level and is accompanied by changes in chromatin modifications. Our data suggests that molecular mechanism of aging is regulated at the level of epigenetic activation and repression and, therefore, might be modifiable. Lastly, this work further emphasizes the importance of early diagnosis and prevention as well as age-specific management of age-related eye-diseases, including glaucoma.

2022-11-30 | GSE212187 | GEO

Stress induced accelerated aging in mouse eye [ATAC-seq]

2022-11-30 | GSE212188 | GEO