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ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion [HTGTS]

ABSTRACT: ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion [HTGTS]

PROVIDER: PRJNA874445 | ENA |

REPOSITORIES: ENA

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ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion [HTGTS]

Project description:The ATR kinase, which coordinates cellular responses to DNA replication stress, is also essential for the proliferation of normal unstressed cells. Although its role in the replication stress response is well defined, the mechanisms by which ATR supports normal cell proliferation remain elusive. Here, we show that Atr is dispensable for the viability of G0-arrested naïve B cells. However, upon cytokine-induced proliferation, Atr-deficient B cells initiate DNA replication efficiently in early S phase, but by mid-S phase they display dNTP depletion, fork stalling, and replication failure. Nonetheless, productive DNA replication can be restored in Atr-deficient cells by pathways that suppress origin firing, such as downregulation of CDC7 and CDK1 kinase activities. Together, these findings indicate that ATR supports the proliferation of normal unstressed cells by tempering the pace of origin firing during the early S phase to avoid exhaustion of dNTPs and other replication factors.

2022-12-31 | GSE212195 | GEO

ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion [RNA-seq]

2022-12-31 | GSE212194 | GEO

ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion [CRISPR-Cas9 gRNA screen]

2022-12-31 | GSE214643 | GEO

ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion.

Project description:ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion.

| PRJNA874443 | ENA

ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion [RNA-seq]

Project description:ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion [RNA-seq]

| PRJNA874444 | ENA

ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion [CRISPR-Cas9 gRNA screen]

Project description:ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion [CRISPR-Cas9 gRNA screen]

| PRJNA886447 | ENA

ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion.

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-12-31 | GSE212196 | GEO

Transcription profiling of shoot apices from Arabidopsis wild type, teb, atr, and teb atr mutant plants

Project description:Global gene expression patterns were compared among wild-type Col-0, teb, atr, teb atr of A. thaliana using shoot apices.

2008-04-01 | E-MEXP-1329 | biostudies-arrayexpress

The physiological role of 3’CBEs in antibody class switching (3C-HTGTS)

Project description:We performed CSR-HTGTS-Seq, 3C-HTGTS, GRO-Seq and ChIP-Seq in mature splenic B cells with different stimulation study physiological roles of 3'CBEs in antibody class switching

2021-01-01 | GSE162009 | GEO

The physiological role of 3’CBEs in antibody class switching (CSR-HTGTS-Seq)

Project description:We performed CSR-HTGTS-Seq, 3C-HTGTS, GRO-Seq and ChIP-Seq in mature splenic B cells with different stimulation study physiological roles of 3'CBEs in antibody class switching

2021-01-01 | GSE152190 | GEO

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