Project description:Primary outcome(s): Development of Gene - Environmental interaction risk score methodology and Gene - Environmental Risk Score (GERS) of colorectal cancer;Development of high risk criteria that could be applied final GERS prediction model
Study Design: Observational Study Model : Cohort, Time Perspective : Other(Prospective+Retrospective), Enrollment : 270000, Biospecimen Retention : Collect & Archive- Sample with DNA, Biospecimen Description : whole blood, serum, urine
Project description:The aim of this study was to extend our analysis to the obligate human pathogen M. tuberculosis, which has to deal with a more restricted set of environmental variables in terms of nitrogen sources, and to delineate the GlnR regulon, by peforming global analysis of GlnR-DNA interactions by Chromatin Immunoprecipitation and high-throughput sequencing (ChIP-seq) over nitrogen run-out.