Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Analysis of exosomal miRNAs in MCF7 cells regulated by LSD1

ABSTRACT: Analysis of exosomal miRNAs in MCF7 cells regulated by LSD1

PROVIDER: PRJNA874891 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR21314437.fastq.gz	Fastqsanger.gz
	SRR21314438.fastq.gz	Fastqsanger.gz
	SRR21314439.fastq.gz	Fastqsanger.gz
	SRR21314440.fastq.gz	Fastqsanger.gz
	SRR21314441.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 9

Similar Datasets

Analysis of exosomal miRNAs in MCF7 cells regulated by LSD1

Project description:Lysine specific demethylase 1 (LSD1) is an important histone demethylase that mediates metastasis in luminal breast cancer. Exosomes play a major role in cell-to-cell communication. Thus, the characterization of miRNAs of exosome in MCF7 cells regulated by LSD1 is imperative in clarifying intercellular signaling.

2024-03-04 | GSE212291 | GEO

Analysis of miRNAs in MCF7 cells regulated by LSD1

Project description:Lysine specific demethylase 1 (LSD1) is an important histone demethylase that mediates metastasis in luminal breast cancer. Thus, the characterization of miRNAs in MCF7 cells regulated by LSD1 is imperative in clarifying intercellular signaling.

2024-03-04 | GSE218200 | GEO

Analysis of cellular and exosomal miRNAs in MCF7 cells regulated by LSD1 (miRNA-Seq)

Project description:Analysis of cellular and exosomal miRNAs in MCF7 cells regulated by LSD1 (miRNA-Seq)

| PRJNA1103812 | ENA

Analysis of miRNAs in MCF7 cells regulated by LSD1

Project description:Analysis of miRNAs in MCF7 cells regulated by LSD1

| PRJNA902734 | ENA

Analysis of cellular and exosomal miRNAs in MCF7 cells regulated by LSD1 (miRNA-Seq)

Project description:Lysine-specific demethylase 1 (LSD1), a histone demethylating enzyme, plays a crucial role in cancer metastasis. While studies have demonstrated that the knockout of LSD1 significantly enhances lung metastasis of breast cancer cells, it remains unclear whether LSD1-deficient breast cancer cells can remodel the lung microenvironment to allow metastasis. In this study, we isolated exosomes from LSD1-knockdown breast cancer cells (LSD1 KD) and investigated their effects on the formation of pre-metastatic niches. The intravenous injection of exosomes from LSD1 KD cells in mice resulted in a substantial increase in lung colonization by breast cancer cells, while treatment with exosomes derived from LSD1 KD cells decreased the expression of the tight junction proteins ZO-1 and occludin in vascular endothelial cells, leading to increased pulmonary vascular permeability. In addition, the knockdown of LSD1 reduced the expression of the circular RNA circDOCK1, which augmented the levels of miR-1270 in exosomes. Further investigation showed that miR-1270 inhibited ZO-1 expression in human umbilical vein endothelial cells, which enhanced their permeability. In conclusion, our study uncovered a novel mechanism in which the epigenetic modifier LSD1 promotes the formation of pre-metastatic niches via the regulation of exosomal miRNA.

2024-09-12 | GSE264698 | GEO

Analysis of cellular and exosomal circRNAs in MCF7 cells regulated by LSD1 (RNA-Seq)

Project description:Analysis of cellular and exosomal circRNAs in MCF7 cells regulated by LSD1 (RNA-Seq)

| PRJNA1103819 | ENA

Analysis of cellular and exosomal circRNAs in MCF7 cells regulated by LSD1 (RNA-Seq)

2024-09-12 | GSE264699 | GEO

Analysis of exosomal miRNAs upon irradiation in pancreatic cancer cells

Project description:We used miRNA-seq and bioinformatics to analyze and annotate the expression profiles exosomal miRNAs in pancreatic cancer cells after radiation, compared with the unirradiated cells. A total of 481 miRNAs were identified, and 284 miRNAs were annotated in miRBase. There were 22 filtered differentially expressed miRNAs (9 for up-regulated and 13 for down-regulated, fold change > 2, p-value < 0.05). This study provides the results of exosomal miRNA change in pancreatic cancer cells after radiation.

2020-06-14 | GSE138983 | GEO

MYCN regulated miRNAs

Project description:MYCN regulated miRNAs

| PRJEB6787 | ENA

Exosomal miRNAs from serum sequencing

Project description:Exosomal miRNAs from serum sequencing

| PRJNA1100526 | ENA