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ABSTRACT: Gut microbiota of pregnant women

PROVIDER: PRJNA876635 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21414600.fastq.gz	Fastqsanger.gz
	SRR21414601.fastq.gz	Fastqsanger.gz
	SRR21414602.fastq.gz	Fastqsanger.gz
	SRR21414603.fastq.gz	Fastqsanger.gz
	SRR21414604.fastq.gz	Fastqsanger.gz

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Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice.

Project description:Antibiotics have long-lasting consequences on the gut microbiota with the potential to impact host physiology and health. However, little is known about the transgenerational impact of an antibiotic-perturbed microbiota. Here we demonstrated that adult pregnant female mice inoculated with a gut microbial community shaped by antibiotic exposure passed on their dysbiotic microbiota to their offspring. This dysbiotic microbiota remained distinct from controls for at least 5 months in the offspring without any continued exposure to antibiotics. By using IL-10 deficient mice, which are genetically susceptible to colitis, we showed mice that received an antibiotic-perturbed gut microbiota from their mothers had increased risk of colitis. Taken together, our findings indicate that the consequences of antibiotic exposure affecting the gut microbiota can extend to a second generation.

2017-12-01 | GSE92623 | GEO

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