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PD-1 instructs a tumor suppressive metabolic program to restrain AP-1 activity in T cell lymphoma

ABSTRACT: PD-1 instructs a tumor suppressive metabolic program to restrain AP-1 activity in T cell lymphoma

PROVIDER: PRJNA877609 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21463225_1.fastq.gz	Fastqsanger.gz
	SRR21463225_2.fastq.gz	Fastqsanger.gz
	SRR21463226_1.fastq.gz	Fastqsanger.gz
	SRR21463226_2.fastq.gz	Fastqsanger.gz
	SRR21463227_1.fastq.gz	Fastqsanger.gz

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PD-1 instructs a tumor suppressive metabolic program to restrain AP-1 activity in T cell lymphoma

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PD-1 instructs a tumor suppressive metabolic program to restrain AP-1 activity in T cell lymphoma

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Project description:Immunoediting sculpts immunogenicity and thwarts host anti-tumor responses in tumor cells during tumorigenesis; however, it remains unknown whether metabolic programming of tumor cells can be guided by immunosurveillance. Here, we report that T cell-mediated immunosurveillance in early staged tumorigenesis instructs c-Myc upregulation and metabolic reprogramming in tumor cells. This previously unexplored tumor-immune interaction is controlled by a non-canonical IFNg-STAT3 signaling and supports tumor immune evasion. Our findings uncover that immunoediting instructs deregulated bioenergetic programs in tumor cells for empowering them to disarm the T cell-mediated immunosurveillance by imposing metabolic tug-of-war between tumor and infiltrating T cells and forming the suppressive tumor microenvironment.

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