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Effect of SLC7A9 on gene expression in AGS gastric cancer cells

ABSTRACT: Effect of SLC7A9 on gene expression in AGS gastric cancer cells

PROVIDER: PRJNA877866 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21484507_1.fastq.gz	Fastqsanger.gz
	SRR21484507_2.fastq.gz	Fastqsanger.gz
	SRR21484508_1.fastq.gz	Fastqsanger.gz
	SRR21484508_2.fastq.gz	Fastqsanger.gz
	SRR21484509_1.fastq.gz	Fastqsanger.gz

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Effect of SLC7A9 on gene expression in AGS gastric cancer cells

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mRNA profiling of AGS Gastric Cancer cell line treated with the Homeopathy formulation, Ornithogalum

Project description:Ornithogalum is one of the therapeutic formulation used in homeopathic treatments. It is specifically used in the treatment for gastric and duodenal ulcerations. Towards understanding the anticancer mechanism, we investigated the genome-wide mRNA changes upon treating AGS Gastric Cancer cells with Ornithogalum. We observed that totally 707 genes were significantly regulated upon Ornithogalum Treatment, among them 246 genes were upregulated and 461 genes were downregulated. The results provide insight into molecular implication and gene level expression of AGS upon treatment with Ornithogalum. Total RNA was isolated from AGS gastric cancer cells treated with 0.01% of ornithogalum and ethanol control and profiled using Affymetrix Human Gene 1.0 ST Array (HuGene-1_0-st).

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Project description:Beta-catenin (CTNNB1) is a major component of Wnt signaling pathway and a crucial player in gastric cancer. To delineate the complex transcription program governed by CTNNB1 in gastric cancer cells, CTNNB1 was silenced in AGS, a commonly used Wnt signaling activated gastric cancer cell line and the resultant changes in genome-wide mRNA expression pattern was profiled using Affymetrix Human Gene 1.0 ST Array.

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Gene expression profiling of AGS Gastric Cancer cells upon YY1 knock down

Project description:Yin Yang 1 (YY1) is a ubiquitous transcription factor belonging to the GLI-Kruppel class of zinc finger proteins regulating diverse biological processes including cell proliferation, development, DNA damage responses and also involved in carcinogenesis. The protein is involved in repressing and activating a diverse number of promoters.In order to study the role of the transcription factor YY1 in gastric cancer, transcriptome wide gene expression analysis was performed upon silencing the YY1 gene in gastric cancer cell line, AGS using Affymetrix Human Transcriptome 2.0 array. Transcriptome Analysis Console (TAC) Software was used for the analysis of differentially expressed genes between AGS_YY1_siRNA transfected and AGS_NTC_siRNA transfected cells.

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Effect of GPX4 knockdown on gene expression profile of EBV positive gastric cancer cell line AGS-EBV.

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