Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [4C-Seq]

ABSTRACT: Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [4C-Seq]

PROVIDER: PRJNA878689 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR21497055.fastq.gz	Fastqsanger.gz
	SRR21497056.fastq.gz	Fastqsanger.gz
	SRR21497057.fastq.gz	Fastqsanger.gz
	SRR21497058.fastq.gz	Fastqsanger.gz
	SRR21497059.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 25

Similar Datasets

Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [4C-Seq]

Project description:To model and characterize the chromatin regulatory landscape of the very first developmental cell fates, we made use of three previously derived and well-characterized Trophoblast Stem Cell (TSCs), Embryonic Stem Cell (ESC) and Extra Embryonic Stem Cell lines (XENs) We performed high-resolution in situ 4C-seq analysis around enhancers and promoters of cell-type specific genes (e.g. Sox17 for XEN and Nanog for ESC), which showed high concordance both with the virtual 4C of HiChIP and the called HiChIP contacts in the respective cell type

2023-08-21 | GSE212992 | GEO

Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions

Project description:Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions

| PRJNA882009 | ENA

Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [HiChIP]

Project description:Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [HiChIP]

| PRJNA882022 | ENA

Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [ChIP-Exo]

Project description:Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [ChIP-Exo]

| PRJNA985766 | ENA

Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [Hi-C]

Project description:Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [Hi-C]

| PRJNA878696 | ENA

Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [ATAC-Seq]

Project description:Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [ATAC-Seq]

| PRJNA878695 | ENA

Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [RNA-Seq]

Project description:Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [RNA-Seq]

| PRJNA882012 | ENA

Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [ChIP-Seq]

Project description:Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [ChIP-Seq]

| PRJNA878697 | ENA

4C-seq: Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

Project description:Hox genes are essential regulators of embryonic development. They are activated in a temporal sequence following their topological order within their genomic clusters. Subsequently, states of activity are fine-tuned and maintained to translate into domains of progressively overlapping gene products. While the mechanisms underlying such temporal and spatial progressions begin to be understood, many of their aspects remain unclear. We have systematically analyzed the 3D chromatin organization of Hox clusters in vivo, during their activation using high-resolution circular chromosome conformation capture (4C-seq). Initially, Hox clusters are organized as single 3D chromatin compartments decorated with bivalent chromatin marks. Their progressive transcriptional activation is associated with a dynamic bi-modal 3D organization, whereby the genes switch one after the other, from an inactive to an active 3D compartment. These local 3D dynamics occur within a larger constitutive framework of interactions within the surrounding Topological Associated Domains, which confirms previous results that regulation of this process in primarily cluster intrinsic. The local step-wise progression in time can be stopped and memorized at various body levels and hence it may accounts for the various chromatin architectures previously described at different anterior to posterior body levels for the same embryo at a later stage. Circular Chromosome Conformation Capture (4C-seq) samples from mouse ES cells and mouse embryonic samples at different stages of development. Data based on 41 biological samples.

2014-04-28 | E-GEOD-55342 | biostudies-arrayexpress

Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [Hi-C]

2023-08-21 | GSE212995 | GEO