Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming (RNA-Seq)

ABSTRACT: Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming (RNA-Seq)

PROVIDER: PRJNA879430 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming

Project description:Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming

| PRJNA962078 | ENA

Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming (WGBS)

Project description:Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming (WGBS)

| PRJNA879422 | ENA

Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming (WGBS)

Project description:We recently demonstrated the chemical reprogramming of human somatic cells to pluripotent stem cells, which provides a fundamentally new approach for cell fate manipulation. However, the utility of this chemical approach is currently hampered by the slow kinetics. Here, by screening for new small-molecule boosters and systematically optimizing the original chemical reprogramming condition, we have established a robust, chemically defined protocol. With this new protocol, the entire chemical reprogramming process is remarkably accelerated, reducing the time needed from ~50 days to a minimum of 16 days. Moreover, this new protocol enables highly reproducible and efficient generation of human pluripotent stem cells from all 17 tested donors with a reprogramming efficiency of up to 31%. Our method provides a unique and powerful strategy for human cell fate manipulation and pluripotent stem cell manufacturing for cell-based therapeutic applications.

2023-04-26 | GSE213160 | GEO

Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming (scATAC-seq)

Project description:Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming (scATAC-seq)

| PRJNA962081 | ENA

Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming (CUT&TAG)

Project description:Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming (CUT&TAG)

| PRJNA961789 | ENA

Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming (scRNA-seq)

Project description:Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming (scRNA-seq)

| PRJNA962012 | ENA

Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming (scATAC-seq)

2023-04-26 | GSE230657 | GEO