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PD-1 instructs a tumor suppressive metabolic program to restrain AP-1 activity in T cell lymphoma [ATAC-seq]

ABSTRACT: PD-1 instructs a tumor suppressive metabolic program to restrain AP-1 activity in T cell lymphoma [ATAC-seq]

PROVIDER: PRJNA879454 | ENA |

REPOSITORIES: ENA

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PD-1 instructs a tumor suppressive metabolic program to restrain AP-1 activity in T cell lymphoma

Project description:PD-1 instructs a tumor suppressive metabolic program to restrain AP-1 activity in T cell lymphoma

| PRJNA976802 | ENA

PD-1 instructs a tumor suppressive metabolic program to restrain AP-1 activity in T cell lymphoma

Project description:PD-1 instructs a tumor suppressive metabolic program to restrain AP-1 activity in T cell lymphoma

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PD-1 instructs a tumor suppressive metabolic program to restrain AP-1 activity in T cell lymphoma

Project description:PD-1 instructs a tumor suppressive metabolic program to restrain AP-1 activity in T cell lymphoma

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PD-1 instructs a tumor suppressive metabolic program to restrain AP-1 activity in T cell lymphoma

Project description:To dissect T cell lymphoma pathogenesis, we previously engineered a genetically controllable murine model of human T-NHL based on tamoxifen-inducible irreversible expression of the T-NHL oncogene ITK-SYK, which enforces strong oncogenic TCR signaling. Three days after ITK-SYK expression, we purified the oncogene-expressing cells by fluorescence-activated cell sorting (FACS) for RNA sequencing.

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PD-1 instructs a tumor suppressive metabolic program to restrain AP-1 activity in T cell lymphoma [ATAC-seq]

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3-AP and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma

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Immunoediting instructs tumor metabolic reprogramming to support immune evasion [smartseq]

Project description:Immunoediting sculpts immunogenicity and thwarts host anti-tumor responses in tumor cells during tumorigenesis; however, it remains unknown whether metabolic programming of tumor cells can be guided by immunosurveillance. Here, we report that T cell-mediated immunosurveillance in early staged tumorigenesis instructs c-Myc upregulation and metabolic reprogramming in tumor cells. This previously unexplored tumor-immune interaction is controlled by a non-canonical IFNg-STAT3 signaling and supports tumor immune evasion. Our findings uncover that immunoediting instructs deregulated bioenergetic programs in tumor cells for empowering them to disarm the T cell-mediated immunosurveillance by imposing metabolic tug-of-war between tumor and infiltrating T cells and forming the suppressive tumor microenvironment.

2022-11-15 | GSE217862 | GEO

Immunoediting instructs tumor metabolic reprogramming to support immune evasion [ExomeSeq]

2022-11-15 | GSE217479 | GEO

Immunoediting instructs tumor metabolic reprogramming to support immune evasion [ATAC-seq]

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