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Effect of IFNg on gene expression of CD90pos and CD90neg PyMT tumors

ABSTRACT: Effect of IFNg on gene expression of CD90pos and CD90neg PyMT tumors

PROVIDER: PRJNA880270 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21545528.fastq.gz	Fastqsanger.gz
	SRR21545529.fastq.gz	Fastqsanger.gz
	SRR21545530.fastq.gz	Fastqsanger.gz
	SRR21545531.fastq.gz	Fastqsanger.gz
	SRR21545532.fastq.gz	Fastqsanger.gz

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Effect of IFNg on gene expression of CD90pos and CD90neg PyMT tumors

Project description:To investigate effect of IFNg in the plasticity of PyMT, we treated PyMT with IFNg for 24h then FACS sorted the CD90pos and CD90neg PyMT. We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 different PyMT cells

2023-05-01 | GSE213252 | GEO

Effect of Spot14 Loss on Gene Expression Profile of MMTV-PyMT Mouse Tumors

Project description:The objective of this study was to determine the effect of Thyroid Hormone Responsive Protein Spot14 (Spot14) loss on the gene expression profiles of tumors from MMTV-Polyomavirus middle-T antigen (PyMT) mice. MMTV-PyMT/S14-heterozygous mice were crossed with S14-heterozygous mice and 1 cm tumors from MMTV-PyMT control (wild-type S14) or MMTV-PyMT/S14-null offspring were profiled using Affymetrix gene arrays. Tumor latency was not different between groups; however, tumors lacking S14 grew significantly slower than control tumors. Loss of S14 also decreased the levels of de novo synthesized fatty acids in mammary tumors. In additional studies, performed on MMTV-Neu mice, we found that S14 overexpression was associated with increased tumor cell proliferation and elevated levels of tumor fatty acids. Gene expression profiling revealed that S14 loss and overexpression in mouse mammary tumors altered pathways associated with proliferation and metabolism. This study provides important information about the role of S14 in mammary tumorigenesis and tumor metabolism. Microarray analysis was performed on 4 mammary tumors from MMTV-PyMT mice and 4 tumors from MMTV-PyMT/S14-null mice.

2014-09-01 | E-GEOD-55886 | biostudies-arrayexpress

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Expression data from MMTV-PyMT Induced Tumors

Project description:Loss of E2F transcription factos alters metastatic capacity of MMTV-PyMT tumors. We used microarrays to futher characterize the effects of E2F loss on mammary tumorigenesis in MMTV-PyMT mice.

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Differential Gene expression in the mouse mammary tumors of PyMT-Malat1 wild-type (WT), PyMT-Malat1 knockout (KO) and PyMT-Malat1 knockout with Malat1 transgene expression (TG)

Project description:Previously, lncRNA Malat1 knockout mice were generated by insertional inactivation. By crossing this line to MMTV-PyMT mammary tumor mouse model, we produced PyMT;Malat1 wild-type (WT) and PyMT;Malat1 knockout (KO). Furthermore, we generated Malat1 transgenic mice by targeting ROSA26 locus and bred them to PyMT;Malat1 knockout mice to produce Malat1-rescued PyMT;Malat1 knockout;Malat1 transgenic animals (TG). Using mammary tumors from the three groups of animals, we performed RNA-Seq analysis to identify differentially up-regulated genes in KO tumors to find novel target genes of YAP-TEAD pathway.

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Expression data from MMTV-PyMT Induced Tumors

Project description:Expression data from MMTV-PyMT Induced Tumors

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Gene expression profiles of the mammary gland tumors from Nr1d1+/+ PyMT and Nr1d1-/- PyMT mice

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Gene expression signature in ablated IL-38 PyMT tumors dependent on T cells

Project description:We studied the impact of IL-38 neutralization on tumor immune control in PyMT mammary carcinoma mouse model via γδ T cells. To that end, whole transcriptome profile of PyMT tumors upon in vivo IL-38 neutralization and γδ-TCR blockage were generate via next generation mRNA sequencing on a NextSeq 2000 sequencer.

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Project description:We compared the transcriptional profile of mammary tumors spontaneously developed in PyMT transgenic mice either bearing or not additional copies of the endogeneous SIRT6 gene.

2017-01-20 | GSE93837 | GEO

Gene expression profiles of the mammary gland tumors from Nr1d1+/+;PyMT and Nr1d1-/-;PyMT mice

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