Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq of hiPSCs derived mosaic Down syndrome (undi)

ABSTRACT: RNA-seq of hiPSCs derived mosaic Down syndrome (undi)

PROVIDER: PRJNA880683 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR21615633_1.fastq.gz	Fastqsanger.gz
	SRR21615633_2.fastq.gz	Fastqsanger.gz
	SRR21615634_1.fastq.gz	Fastqsanger.gz
	SRR21615634_2.fastq.gz	Fastqsanger.gz
	SRR21615635_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Down Syndrome

Project description:Down Syndrome

| PRJNA804910 | ENA

Klinefelter syndrome derived hiPSCs show similar XCI behavior as female hPSCs

Project description:In this study, we reprogrammed fibroblasts from two azoospermic Klinefelter syndrome (KS) patients, and two healthy male and one healthy female donor with an efficient integration-free method using episomal plasmids and laminin-521 (LN521). Whole genome transcriptomics analysis showed differentially expressed genes between KS and healthy male donors with enrichment in gene ontology (GO) terms associated with fertility, cardiovascular development, ossification and brain development, for both KS hiPSCs and fibroblasts, correlating with the KS clinical phenotype. Thorough XCI analysis combining transcriptomics data, RNA FISH and H3K27me3 staining, revealed skewed XCI in one KS fibroblast line and variability in XCI state of KS hiPSCs similar to female hiPSCs, showing either XaXi or XaXe status. Furthermore, we found up-regulated X-linked genes involved in nervous system development, synaptic transmission as well as metabolic processes supporting the potential use of KS derived hiPSC as an in vitro model for KS.

2019-10-05 | E-MTAB-7340 | biostudies-arrayexpress

RNA-seq of hiPSCs derived mosaic Down syndrome (undi)

Project description:To know gene expression patterns affected by 3 copies of chromosome 21

2024-03-13 | GSE213409 | GEO

Klinefelter syndrome derived hiPSCs show similar XCI behavior as female hPSCs

Project description:Klinefelter syndrome derived hiPSCs show similar XCI behavior as female hPSCs

| PRJEB29388 | ENA

Migration deficits of neural crest caused by CXADR triplication in a Human Down Syndrome Stem Cell Model

Project description:Here, Down syndrome-specific hiPSCs (DS1-hiPSCs and DS2-hiPSCs) were induced to differentiate to neural crest stem cells (NCSCs). We sequenced mRNA samples of DS1-NCSCs and DS2-NCSCs to generate the gene expression profiles of these cells.

2022-12-02 | GSE190305 | GEO

Induced-pluripotent stem-derived vascular endothelial cells in Down syndrome

Project description:Induced-pluripotent stem-derived vascular endothelial cells in Down syndrome

| PRJNA839280 | ENA

Gene expression profiling in periodontal ligament cells derived from Down syndrome

Project description:We performed the microarray analysis for gene expression profiling in periodontal ligament cells derived from Down syndrome.

2021-01-17 | GSE143885 | GEO

RNA-seq of hiPSCs-derived NPCs from 3 pairs of dizygotic discordant twins for Congenital Zika syndrome

Project description:Congenital Zika syndrome (CZS), caused by Zika virus (ZIKV) infection, has been associated to impairment of early brain development, particularly related to neural progenitor cells (NPCs) survival and growth. In this work we report in a high-throughput manner (RNA-Seq) the differences in the transcriptomes of hiPSCs(human induced pluripotent stem cells)-derived NPCs from 3 pairs of discordant twins for Congenital Zika syndrome (CZS). We found significant differences in the expression levels of genes relevant to the regulation of neural development between the NPCs from CZS-affected and non-affected twins, suggesting that epigenetic differences may contribute to the different susceptibilities of NPCs to ZIKV infection.

2018-02-27 | GSE102128 | GEO

Gene expression profiling in periodontal ligament cells derived from Down syndrome

Project description:Gene expression profiling in periodontal ligament cells derived from Down syndrome

| PRJNA601981 | ENA

Transcriptome study of MX1 overexpression on down syndrome derived aminocytes(DSACs)

Project description:Transcriptome study of MX1 overexpression on down syndrome derived aminocytes(DSACs)

| PRJNA995604 | ENA