Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

De novo Characterization of Cell-free DNA Fragmentation Hotspots in Plasma Whole-genome Sequencing.

ABSTRACT: De novo Characterization of Cell-free DNA Fragmentation Hotspots in Plasma Whole-genome Sequencing.

PROVIDER: PRJNA881452 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

De novo Characterization of Cell-free DNA Fragmentation Hotspots in Plasma Whole-genome Sequencing.

Project description:De novo Characterization of Cell-free DNA Fragmentation Hotspots in Plasma Whole-genome Sequencing.

| PRJNA881451 | ENA

FinaleMe: Predicting DNA Methylation by the Fragmentation Patterns of Plasma Cell-free DNA

Project description:FinaleMe: Predicting DNA Methylation by the Fragmentation Patterns of Plasma Cell-free DNA

| PRJNA965897 | ENA

FinaleMe: Predicting DNA Methylation by the Fragmentation Patterns of Plasma Cell-free DNA

Project description:FinaleMe: Predicting DNA Methylation by the Fragmentation Patterns of Plasma Cell-free DNA

| PRJNA965896 | ENA

De novo deletions and duplications at recombination hotspots in mouse germlines

Project description:Numerous DNA double-strand breaks (DSBs) arise during meiosis to initiate homologous recombination. These DSBs are usually repaired faithfully, but here we uncover a new type of mutational event in which deletions form via joining of ends from two closely-spaced DSBs (double cuts) within a single hotspot or at adjacent hotspots on the same or different chromatids. Deletions occur in normal meiosis but are much more frequent when DSB formation is dysregulated in the absence of the ATM kinase. Events between chromosome homologs point to multi-chromatid damage and aborted gap repair. Some deletions contain DNA from other hotspots, indicating that double cutting at distant sites creates substrates for insertional mutagenesis. End joining at double cuts can also yield tandem duplications or extrachromosomal circles. Our findings highlight the importance of DSB regulation and reveal a previously hidden potential for meiotic mutagenesis that is likely to affect human health and genome evolution.

2021-10-01 | GSE182210 | GEO

Genome-wide cell-free DNA fragmentation in patients with cancer

Project description:Genome-wide cell-free DNA fragmentation in patients with cancer

| PRJNA543357 | ENA

Genome-wide cell-free DNA fragmentation in patients with cancer

Project description:Genome-wide cell-free DNA fragmentation in patients with cancer

| PRJNA543358 | ENA

Genome-wide analysis of cfDNA fragmentation patterns and nucleosome positioning in dual enzyme-digested NIPT quality control materials (DENQCMs) and maternal plasma

Project description:The genome-wide analysis of cfDNA fragmentation patterns in DENQCMs and maternal plasma was performed by deep sequencing using Illumina Novaseq to confirm their biological characteristics. We first performed deep whole genome sequencing of the cfDNA extracted from DENQCMs and maternal plasma cfDNA. Then we analyzed the sequencing data and compared various characteristics of cfDNA fragmentation patterns, such as dinucleotide composition, nucleosome protection length, and nucleosome occupancy based on a windowed protection score (WPS), to the submitter-provided processed data from a healthy individual IH01 (GEO accession GSM1833276).

2019-01-05 | GSE124686 | GEO

Dnase1l3 knockout causes aberrations in plasma DNA fragmentation

Project description:Dnase1l3 knockout causes aberrations in plasma DNA fragmentation

| EGAS00001003174 | EGA

Epigenomics of Prostate Cancer from Cell Free Plasma

Project description:Epigenomics of Prostate Cancer from Cell Free Plasma

| PRJNA1047253 | ENA

Epigenomics of Prostate Cancer from Cell Free Plasma

Project description:Epigenomics of Prostate Cancer from Cell Free Plasma

| PRJNA1047258 | ENA