Project description:In mammals brain evolution, specifically that of the cerebellum, is a focus of evolutionary change. Here we functionally characterize the phylogenetically-restricted novel gene, piggyBac transposable element. The ChiP-exonuclease assay protocol was performed as in Serandour's method. The libraries were quantified by using the KAPA library quantification kit for Illumina sequencing platforms (KAPA Biosystems, KK4824) and sequenced on HiSeq following the manufacturer’s protocol.

2022-09-23 | GSE213758 | GEO

A novel mammalian gene controls mammal-specific neuronal functioning [RNA-Seq]

Project description:n mammals brain evolution, specifically that of the cerebellum, is a focus of evolutionary change. Here we functionally characterize the phylogenetically-restricted novel gene, piggyBac transposable

2022-09-23 | GSE213757 | GEO

Neuronal chromatin remodeling factors in the mammalian nervous system

Project description:Neuronal chromatin remodeling factors in the mammalian nervous system

| PRJNA981553 | ENA

Transcriptional changes associated with functioning and non-functioning Pituitary adenomas.

Project description:Transcriptional changes associated with functioning and non-functioning Pituitary adenomas.

| PRJNA831798 | ENA

Transcriptional Basis of Neuronal Diversity in the Mammalian Brain

Project description:Neuronal diversity is a defining feature of the mammalian brain deemed necessary for realizing the complex function of the nervous system. In order to begin to understand the transcriptional basis of this diversity, we collected more than 170 neuronal and non-neuronal cell type-specific transcriptomes defined operationally by transgenic mouse lines and anatomical regions. The dataset indicates that the genes specifically expressed in neuronal cell types are biased toward long genes. We revealed that these long genes have higher capacities to be differentially expressed between cell types and thus assume an important role in diversification of the neuronal transcriptomes. Since mobile element insertions are the main cause of the gene elongations, we propose that exaptation of the inserted mobile elements significantly contributed to the neuronal diversity.

2018-07-20 | GSE79238 | GEO

BCM-HGSC Marine Mammal Genome Projects

Project description:BCM-HGSC Marine Mammal Genome Projects

| PRJNA170427 | ENA

Non-functioning pituitary adenomas AmpliSeq data

Project description:Non-functioning pituitary adenomas AmpliSeq data

| PRJNA563652 | ENA