Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Metabolic Characterization of Patient-derived Xenograft Models of Clear Cell Renal Cell Carcinoma Transcriptomic Analysis

ABSTRACT: Metabolic Characterization of Patient-derived Xenograft Models of Clear Cell Renal Cell Carcinoma Transcriptomic Analysis

PROVIDER: PRJNA882803 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR21658800_1.fastq.gz	Fastqsanger.gz
	SRR21658800_2.fastq.gz	Fastqsanger.gz
	SRR21658801_1.fastq.gz	Fastqsanger.gz
	SRR21658801_2.fastq.gz	Fastqsanger.gz
	SRR21658802_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 94

Similar Datasets

Patient derived clear cell renal cell carcinoma models.

Project description:Tracing clonal dynamics reveals that 2D and 3D patient-derived cell models capture tumor heterogeneity of clear cell renal cell carcinoma

| PRJEB32502 | ENA

Clear-cell renal cell carcinomas tumors

Project description:Whole genome expression of 39 clear-cell renal cell carcinomas tumors 39 frozen tissue from recent nephrectomies for clear-cell renal cell carcinoma; association with clinical characteristics

2011-05-28 | E-GEOD-29609 | biostudies-arrayexpress

Metabolic Characterization of Patient-derived Xenograft Models of Clear Cell Renal Cell Carcinoma Transcriptomic Analysis

Project description:To investigate the metabolic characterization difference of patient-derived xenograft models in transcriptome level.

2022-09-24 | GSE213857 | GEO

Clear-cell renal cell carcinomas tumors

Project description:Whole genome expression of 39 clear-cell renal cell carcinomas tumors

2011-05-28 | GSE29609 | GEO

CTSP Kidney Renal Clear Cell Carcinoma E2805T6

Project description:CTSP Kidney Renal Clear Cell Carcinoma E2805T6

| PRJNA562745 | ENA

Study of non-clear cell renal cell carcinoma

Project description:Study of non-clear cell renal cell carcinoma

| EGAS00001000926 | EGA

The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma

Project description:The ubiquitin proteasome system governs a wide spectrum of cellular events and offers therapeutic opportunities for pharmacological intervention in cancer treatment. Renal clear cell carcinoma represents the predominant histological subtype and accounts for the majority of cancer death related to kidney malignancies. Through a systematic survey in the association of human ubiquitin-specific proteases with patient prognosis of renal clear cell carcinoma and subsequent phenotypic validation, we uncovered the tumor-promoting role of USP35. Biochemical characterizations confirmed the stabilizing effects of USP35 towards multiple members of the IAP family in an enzymatic activity-dependent manner. USP35 silencing led to reduced expression levels of IAP proteins, which were accompanied with increased cellular apoptosis. Further transcriptomic analysis revealed that USP35 knockdown altered expression levels of NRF2 downstream transcripts, which were conferred by compromised NRF2 abundance. USP35 functions to maintain NRF2 levels by catalyzing its deubiquitylation and thus antagonizing degradation. NRF2 reduction imposed by USP35 silencing rendered renal clear cell carcinoma cells increased sensitivity to ferroptosis induction. Finally, induced USP35 knockdown markedly attenuated xenograft formation of renal clear cell carcinoma in nude mice. Hence, our findings identify a number of USP35 substrates and reveal the protecting role of USP35 against both apoptosis and ferroptosis in renal clear cell carcinoma.

2023-06-17 | GSE216154 | GEO

Expression data from renal cancer patient-derived xenograft tumor treated with temsirolimus or vehicle

Project description:We kept 2 types of primary xenograft models (KURC;Kyoto University Renal Cancer-1,3) derived from human renal cell carcinoma tissues, and 10 mg/kg of temsirolimus or vehicle was intraperitoneally administered.We performed microarray analysis to compare the gene expression profile of temsirolimus-treated primary xenograft tumors with that of vehicle-treated.

2019-12-31 | GSE133446 | GEO

Radiomic and transcriptomic analysis for understanding metastatic clear cell renal cell carcinoma

Project description:To understand the relationship of radiomic and transcriptomic features of metastatic clear cell renal cell carcinoma, we performed RNA-sequencing in clear cell renal cell carcinomas (ccRCCs).

2019-09-30 | GSE135091 | GEO

Side Population Analysis in Clear Cell Renal Cell Carcinoma

Project description:Side Population Analysis in Clear Cell Renal Cell Carcinoma

| PRJNA779732 | ENA