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Expression data from human endometrial stromal cells (HESCs) treated with PRP

ABSTRACT: Expression data from human endometrial stromal cells (HESCs) treated with PRP

PROVIDER: PRJNA882833 | ENA |

REPOSITORIES: ENA

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Expression data from human endometrial stromal cells (HESCs) treated with PRP

Project description:In IVF treatment, the effects of intrauterine platelet-rich plasma (PRP) infusion with increasing rate of successful pregnancy have been reported; however, the mechanisms that support embryo implantation remain unclear. In the undifferentiated HESCs, PRP was found to strongly promote the gene expression associated with cell growth, tissue regeneration, proinflammatory response, and antibiotic effects. In decidualized HESCs, PRP was found to attenuate the gene expression involved in cell proliferation and inflammation by inhibiting the expression of PI3K signaling.

2022-09-24 | GSE213873 | GEO

Expression data from ATRA-treated endometrial stromal cells

Project description:Decidualization is critical for the embryonic implantation and successful pregnancy. ATRA can suppress in-vitro decidualization of human endometrial stromal cells (hESCs) induced by MPA and estrogen treatment. However, the mechanism by which RA suppressed estrogen and progesterone induced decidualization of mESCs is not clear. We used microarrays to investigate the mechanism by which all-trans RA (ATRA) regulates the decidualization of endometrial stroma cells (mESCs).

2013-11-05 | GSE52033 | GEO

Expression data from ATRA-treated endometrial stromal cells

2013-11-05 | E-GEOD-52033 | biostudies-arrayexpress

COUP-TFII regulates human endometrial stromal genes involved in inflammation

Project description:Although the function of COUP-TFII in uterine decidualization has been described in mice, its role in the human uterus remains unknown.To interrogate the role of COUP-TFII in human endometrial function, we utilized a siRNA-mediated loss of function approach in primary human endometrial stromal cells. Primary human endometrial stromal cells (HESCs), coup-TFII siRNA group and control group Two group comparison

2014-01-07 | E-GEOD-47052 | biostudies-arrayexpress

The Promyelocytic Leukemia Zinc Finger Transcription Factor (PLZF) is Critical for Human Endometrial Stromal Cell Decidualization

Project description:Whole genome binding profile of PLZF in human endometrial stromal cells (hESCs)

2016-03-09 | GSE75115 | GEO

GOLPH3 modulates expression and alternative splicing of transcription factors associated with endometrial decidualization in human endometrial stromal cells

Project description:GOLPH3 was silenced in human endometrial stromal cells (hESCs), and the transcriptome data (RNA-seq) by GOLPH3 knockdown (siGOLPH3) was obtained by high-throughput sequencing technology,

2022-10-12 | GSE215155 | GEO

The single cell atlas of human endometrial stromal cells

Project description:Primary human endometrial stromal cells (HESCs) from three patients and the Telomerase-immortalized endometrial stromal cell line (THESC) were cultured in the cluture medium and collected for scRNA-Seq. 13 distinct cell clusters were identified among all the cells, which not only reflect the differences between the four samples, but also the heterogeneity within each sample divided into mature, proliferative and active fibroblast. The conserved transcriptomic changes from the three primary HESC were observed in comparison to the THESCs. Cell clustering with batch correction further indicate that the intrinsic cellular distribution were similar among all the primary HESCs and THESCs. These intrinsic cell clustering showed varaiable stages of cell cycle and a cell development lineage between proliferative and mature or active fibroblast.

2022-11-23 | GSE195918 | GEO

EGR1-controlled transcriptome of T HESCs

Project description:Sequencing of mRNA isolated from a human endometrial stromal cell line (T HESCs) following control or EGR1 siRNA-mediated knockdown.

2019-04-22 | GSE123472 | GEO

Gene expression changes in primary human endometrial stromal cells following METTL3 knockdown during in vitro decidualization

Project description:We developed an in vitro model in which primary human endometrial stromal cells (HESCs) were induced to differentiate through treatment with MPA and 8-Br-cAMP. SiRNA-mediated knockdown of METTL3 was performed on HESCs, 6 h prior to treatment of 8-Br-cAMP and MPA.

2024-04-14 | GSE263330 | GEO

RNA-seq from animals treated with RNAi against prp-8, prp-6, and prp-31

Project description:Transcriptome analysis of a population of control animals and RNAi-treated to partially inactivate genes that are homologs to human genes causing Retinitis Pigmentosa. RNA-seq analyses were performed at L3 larval stage in wild type, and smg-1(r861) mutants that have a defective Non-mediated decay pathway. RNA-seq experiments were also performed in adults glp-4(bn2) mutants that lack of germline. synchronized N2 and smg-1(r861) L1 larvae fed for 24 hours at 20 Â°C with the RNAi clones of prp-6, prp-8, prp-31 and gfp; and 5-day adult glp-4(bn2) worms grown at 25 Â°C and fed first, for 72 hours with OP50 and next, for 48 more hours with the RNAi clones of prp-8, prp-31 and gfp

2016-07-03 | E-GEOD-72952 | biostudies-arrayexpress

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