Project description:Vanin1, a regulator of vitamin B5 metabolism, is expressed by sarcoma tumors. We evaluated its impact on sarcoma growth by using sarcoma cell lines derived from p16p19Vnn1-deficient mice and further transduced with an oncogenic RasV12 oncogene (R tumors) in the presence or not of a catalytically active (VR tumors) or mutated (VdR tumors) Vnn1 isoform. We used microarrays to detail the global programme of gene expression associated with the growth potential of various tumor cell lines grafted in Nude mice

2018-08-26 | GSE107686 | GEO

Gene expression in sarcoma cell lines

Project description:As a high-grade soft-tissue sarcoma (STS), undifferentiated pleomorphic sarcoma (UPS) is highly recurrent and malignant. UPS is categorized as “tumor of uncertain differentiation” and few options for treatment resulting from lack of targetable genetic alterations. There are also few cell lines representative subtype for UPS, leading to poor experimental evidence. Here, we have established and characterized new cell lines derived from recurrent two UPS tissues. Cells were obtained UPS tissues by mincing followed by extracting or dissociating using enzymes and cultured by regular culture environment. Cells were maintained and immortal for months without artificial treatment and some cell clones were tumorigenic in immunodeficient mouse model. Interestingly, some cells formed tumor in vivo when injected after aggregation in non-adherent culture system for 24 h. The tissues from in vivo study and tissues from patients were compared if it is representative for UPS by immunohistochemistry. Pathways related to cell cycle as DNA replication were common between cell clones while cell clones, tumorigenic in regardless of aggregation for injection, were increased expression of pathways related to cell-cell adhesion, as well as cell-cell signaling, implying a role of mesenchymal to epithelial transition for tumorigenicity in vivo. This study showed that new UPS cell lines might be a good resource for UPS study to get new insights leading to better therapeutic strategy against UPS.

2023-12-31 | GSE213936 | GEO

Single cell transcriptomics of Ewing Sarcoma cell lines

Project description:Single cell transcriptomics of Ewing Sarcoma cell lines

| PRJNA609725 | ENA

Ewing Sarcoma cell lines treated with mithramycin

Project description:The study aims to define gene expression changes associated with mithramycin treatment of Ewing Sarcoma cell lines.

2011-04-18 | GSE25127 | GEO

Methylation profile of ewing sarcoma cell lines

Project description:Methylation profile of ewing sarcoma cell lines

| PRJNA487074 | ENA

Human sarcoma cell lines and untransformed cells

Project description:This study was performed with an overall aim to compare gene expression prolife in human sarcoma cell lines and in primary untransformed cells.

2013-01-01 | GSE39262 | GEO

Gene expression changes between sensitive and YK-4-279-resistant Ewing's Sarcoma cell lines

Project description:Microarray gene expression analysis conducted from cell lines in each of three cohorts: (1) Resistant ES cell lines, (2) Sensitive parental ES cell lines treated with YK-4-279 for 72 hours, and (3) untreated sensitive parental ES cell lines (Three replicates from TC32 & TC71 original parental cell lines) We used microarrays to detail the global programme of gene expression underlying mechanism of resistance to YK-4-279 within parental sensitive and resistant selected Ewing's Sarcoma cell lines. We identified distinct classes of up-regulated genes during this process.

2014-09-04 | GSE61042 | GEO

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