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Super-enhancer-driven PPP1R15B/CReP, regulated by C/EBPβ and YY1, is oncogenic in multiple myeloma [HiChIP I]

ABSTRACT: Super-enhancer-driven PPP1R15B/CReP, regulated by C/EBPβ and YY1, is oncogenic in multiple myeloma [HiChIP I]

PROVIDER: PRJNA883643 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21683860_1.fastq.gz	Fastqsanger.gz
	SRR21683860_2.fastq.gz	Fastqsanger.gz
	SRR21683861_1.fastq.gz	Fastqsanger.gz
	SRR21683861_2.fastq.gz	Fastqsanger.gz
	SRR21683862_1.fastq.gz	Fastqsanger.gz

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Super-enhancer-driven PPP1R15B/CReP, regulated by C/EBPβ and YY1, is oncogenic in multiple myeloma [HiChIP II]

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Super-enhancer-driven PPP1R15B/CReP, regulated by C/EBPβ and YY1, is oncogenic in multiple myeloma

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Super-enhancer-driven PPP1R15B/CReP, regulated by C/EBPβ and YY1, is oncogenic in multiple myeloma

Project description:We identified a novel super-enhance-driven oncogene PPP1R15B overexpressed in multiple myeloma as compared to normal plasma cells and B lymphoma cells. Circular chromosome conformation capture sequencing (4C-seq) was used to confirm the interactions between PPP1R15B enhancer and promoter.

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Super-enhancer-driven PPP1R15B/CReP, regulated by C/EBPβ and YY1, is oncogenic in multiple myeloma [HiChIP I]

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AP-SWATH analysis reveals a direct involvement of VCP/p97 in integrated stress response signalling through CReP/PPP1R15B degradation

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