Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

PM2.5 exposure induces lifespan reduction in Caenorhabditis elegans

ABSTRACT: PM2.5 exposure induces lifespan reduction in Caenorhabditis elegans

PROVIDER: PRJNA884373 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR21711855.fastq.gz	Fastqsanger.gz
	SRR21711856.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

PM2.5 exposure induces lifespan reduction in Caenorhabditis elegans

Project description:To elucidate the molecular mechanism underlying lifespan reduction induced by PM2.5 exposure in Caenorhabditis elegans, we performed global gene expression profiling by RNA-sequencing technology, and compared the gene expression pattern change induced by PM2.5 exposure.

2023-02-22 | GSE214215 | GEO

Bacillus licheniformis isolated from Korean traditional food resources enhances the lifespan of Caenorhabditis elegans through serotonin signaling

2015-11-05 | GSE63056 | GEO

Fine particulate matter (PM2.5) induces microRNA-192–5p causing glomerular damage

Project description:To unravel changes in gene expression due to exposure to PM2.5, we performed bulk RNA-seq analyses of zebrafish larvae exposed to PM2.5 and controls. Among others, PM2.5 increased oxoglutarate alpha-ketoglutarate receptor 1a, nitric oxide synthase, arachidonate 5-lipoxygenase b, immunity-related GTPase family e1, sulfotransferase family 5A, and macrophage expressed 1. NADPH oxidase organizer 1a and NADPH oxidase 1 were upregulated due to PM2.5 exposure. Furthermore, protein tyrosine/serine/threonine phosphatase activity was decreased after exposure to PM2.5. GESA analysis showed that genes involved in proteasome complex formation, inflammatory and immune response, leucocyte-mediated cytotoxicity, peptidase activator activity protein folding, and apoptotic signaling were upregulated after exposure to PM2.5. These results indicate that PM2.5 exposure caused the activation of immune-inflammatory and oxidative stress pathways and lipid and metabolic dysregulation.

2025-05-05 | GSE285038 | GEO

Single-cell gene expression profiles of mice lung tissue under PM2.5 exposure

Project description:Numerous epidemiological studies have demonstrated a significant association between PM2.5 exposure and pulmonary diseases. PM2.5 may contribute to epithelial injury and immune dysregulation in lung cells. In this study, we provide single-cell level gene expression profiles of mouse lungs under PM2.5 exposure, offering insights into the microenvironmental alterations and physiological responses induced by PM2.5.

2025-05-06 | GSE296297 | GEO

Bacillus licheniformis isolated from Korean traditional food resources enhances the lifespan of Caenorhabditis elegans through serotonin signaling

Project description:The C. elegans lifespan in the presence of Bacillus licheniformis caused induction of a large number of genes associated with anti-aging activiy including beta-oxidation Inaddition, these results indicate the B. licheniformis enhances the lifespan of Caenorhabditis elegans through serotonin signaling Two-condition experiment, C. elegans with B. lichemiformis 141 or E. coli OP50 (conrol) for 24 h. For preparing the total RNA, C. elegans were exposed to 20 mg of bacterial lawn in NGN agar for 24 h.

2015-11-05 | E-GEOD-63056 | biostudies-arrayexpress

Transcriptomics profiles in human keratinocytes after PM2.5 exposure

Project description:RNA-seq in normal human epidermal keratinocytes (NHEK) for understanding PM2.5-induced effects

2022-06-22 | GSE143709 | GEO

The effect of exposure to PM2.5 from the cowshed environment on the ovaries of rats

Project description:Fine particulate matter (PM2.5) is toxic to reproduction and can cause a range of reproductive disorders. However, the underlying mechanisms of female reproductive impairment due to cowshed PM2.5 exposure are unclear. The aim of this study was the investigation of the effects of PM2.5 on rat ovaries and its molecular mechanisms. Therefore, this study established a whole-body exposure model of PM2.5 in female rats to investigate the effects of PM2.5 on the ovaries. Exposure of rats to PM2.5 using a small animal whole-body PM2.5 exposure system. The device effectively simulates the exposure of animals or humans to PM2.5 within the barn environment, thereby offering enhanced scientific reference data. To put it briefly, for 30 days, the rats were exposed to six hours a day at four times the actual ambient PM2.5 concentration. Adult rats' respiratory coefficient, single-breath volume, and respiratory frequency were used to quantify their daily exposure to PM2.5. To study the effects of PM2.5 exposure on the ovaries of rats, the rats were divided into 2 groups: rats living in clean air were the Control group (Control), which received no additional treatments, and rats exposed to PM2.5 were the PM2.5-exposed group (PM2.5).

2025-10-10 | GSE294063 | GEO

Wistar rat model of COPD: Cigarette smoking exposure and fine particulate matter (PM2.5) exposure vs. control.

Project description:Genome-wide analysis of lncRNA expression profiles in COPD rat model exposed by cigarette smoking (CS) and fine particulate matter (PM2.5). Goal was to explore the differences and similarities lncRNAs expression in rats model of COPD exposed by CS and PM2.5.

2021-06-21 | GSE178513 | GEO

Effect of pm2.5 maternal exposure on DNA methylation in the offspring myocardium

Project description:The animals were divided into two groups according to exposure of PM2.5 (particulate matter less than 2.5 µm): control group (Non-PM group) or PM exposure group (PM group).PM2.5 at 150 μg/m3were administered by intratracheal instillation during the gestation period of female rats from Day 1 of conception onwards.After the female rat gave birth,the offspring's heart DNA was extracted and anlyzed. DNA promotor methylation profile were determined.The goal was to determine the effects of PM2.5 exposure on the DNA promotor methylation patterns in heart tissue.

2025-04-01 | GSE229560 | GEO

Therapeutic reduction of rad23a extends lifespan and mitigates pathology in TDP-43 mice.

Project description:Therapeutic reduction of rad23a extends lifespan and mitigates pathology in TDP-43 mice. Xueshui Guo, Ravindra Prajapati, Jiyeon Chun, Insuk Byun, Kamil K Gebis, Yi-Zhi Wang, Karen Ling, Casey Dalton, Jeff Blair, Anahid Hamidianjahromi, Jeffrey N. Savas, Min Jae Lee, Jemeen Sreedharan, Robert Kalb

2024-07-12 | MSV000095320 | MassIVE

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data