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Cancer-specific miRNAs Extracted from Tissue-exudative Ex-tracellular Vesicles in Ovarian Clear Cell Carcinoma

ABSTRACT: Cancer-specific miRNAs Extracted from Tissue-exudative Ex-tracellular Vesicles in Ovarian Clear Cell Carcinoma

PROVIDER: PRJNA884425 | ENA |

REPOSITORIES: ENA

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Cancer-specific miRNAs Extracted from Tissue-exudative Ex-tracellular Vesicles in Ovarian Clear Cell Carcinoma

Project description:Ovarian clear cell carcinomas (OCCs) arise from endometriotic cysts that many women develop. Because the prognosis for OCC is poor, there is a need to identify biomarkers for early detection of OCC. Extracellular vesicles have attracted attention as biomarker carriers. This study aimed to identify cancer-specific miRNAs as novel OCC biomarkers using tissue-exudative extracellular vesicles (Te-EVs). Te-EVs were collected from patients with OCC on one side and a normal ovary on the other side. RNA sequencing was performed to identify cancerspecific miRNAs in Te-EVs. We identified tissue-specific miRNAs in the EVs secreted by OCC tissues. These EV miRNAs can be used as biomarkers for the early diagnosis and detection of OCC.

2022-10-01 | GSE214239 | GEO

Comprehensive analysis of miRNAs in matrix vesicles

Project description:miRNAs in matrix vesicles isolated from the extracellular matrix of MC3T3-E1 cell cultures

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Expression data of exosomal miRNAs extracted from serum

Project description:Expression data of exosomal miRNAs extracted from serum

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Urinary Extracellular Vesicles RNA Profile in Clear Cell Renal Cell Carcinoma as Biomarker

Project description:Background: Renal cell carcinoma (RCC) accounts for about 2% of all cancers. Renal biopsy is the gold standard among the diagnostic tools, but it is invasive and not suitable for all patients. Therefore, new reliable and non-invasive biomarkers for ccRCC detection are required. Secretion of extracellular vesicles (EVs), containing RNA molecules that can be transferred between cells, seems to be a general characteristic of malignant transformation. Consistently, cancer-derived EVs are enriched in the blood, urine and various malignant effusions of cancer patients. Therefore, urinary samples can be a non-invasive approach for discovering diagnostic biomarkers. Methods: We enrolled 33 clear-cell RCC (ccRCC) patients and 22 healthy subjects (HS), age and sex-matched, for urine collection and extracellular vesicles isolation by differential centrifugation. Transcriptional profiles of urinary EVs from 12 patients with ccRCC and 11 HS were generated using the Illumina HumanHT-12 v4 BeadChip oligonucleotide arrays. Microarray analysis led to the identification of RNA that were then validated using RT-qPCR. Results: We showed for the first time that urinary exosomal shuttle RNA (esRNA) was significantly different in ccRCC patients compared to HS and we identified three EVs esRNA involved in the tumor biology that are potentially suitable as non-invasive biomarkers. GSTA1, CEBPA and PCBD1 RNA levels decreased in urinary EVs of patients compared to HS. After 1 month post-operation, the levels of RNA increased to reach the normal level. Conclusions: This study suggests, for the first time, the potential use of the RNA content of urinary EVs to provide a non-invasive first step to diagnose the ccRCC. Total RNA obtained from urinary extracellular vesicles isolated from ccRCC patients and healthy subjects.

2016-09-01 | E-GEOD-72922 | biostudies-arrayexpress

Expression data of miRNAs extracted from plasma [Affymetrix miRNA4.0]

Project description:Expression data of miRNAs extracted from plasma [Affymetrix miRNA4.0]

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Expression data from Human seminal vesicles

Project description:The human seminal plasma is a potential source of biomarkers for male reproductive disorders. A tissue-profiling analysis of the main organs participating in the secretion of this body fluid was conducted to identify tissue-specific genes along the male reproductive tract. Total RNA from non pathological Human seminal vesicles were extracted and hybridized on Affymetrix microarrays. Expression signals in seminal vesicles (present dataset), prostates (GEO; GSE7307), epidydimises (GEO; GSE7808) and testicular samples (Arrayexpress; E-TABM-130) were compared to identify genes that are detected in one of these organs only.

2010-06-08 | E-GEOD-17340 | biostudies-arrayexpress

Signatures of protein and small RNA cargoes in extracellular vesicles of mouse testis

Project description:We report the small RNA transcriptome of testicular extracellular vesicles in mouse testis. We established a testis dissociation protocol to isolate testicular extracellular vesicles. After treatment with proteinase K and RNase A, the RNA inside the extracellular vesicles was extracted and sequenced by small RNA-seq.

2022-01-31 | GSE158402 | GEO

miRNAs profile in extracellular vesicles derived from human beta cells

Project description:miRNAs profiles in extracellular vesicles derived from human beta cells were analyzed using RNA-seq

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soil extracted cells

Project description:soil extracted cells Raw sequence reads

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miRNAs in extracellular vesicles prepared from patients with multiple sclerosis

Project description:Differences in the levels of miRNAs in extracellular vesicles (EVs) between multiple sclerosis (MS) patients and healthy individuals were detected by means of microarray analysis.

2017-11-18 | GSE86863 | GEO

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