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CircAFF1 is a circRNA with a role in alveolar rhabdomyosarcoma cell cycle migration

ABSTRACT: CircAFF1 is a circRNA with a role in alveolar rhabdomyosarcoma cell cycle migration

PROVIDER: PRJNA885056 | ENA |

REPOSITORIES: ENA

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CircAFF1 is a circRNA with a role in alveolar rhabdomyosarcoma cell cycle migration

Project description:Circular RNAs (circRNAs), a new division of covalently closed RNA formed by a back-splicing reaction, have been involved in the regulation of diverse processes including those that occur in the development and pathologic processes such as cancer. In this manuscript, we describe circAFF1, a circular RNA overexpressed in representative rhabdomyosarcoma cell lines. We demonstrated that circAFF1 is a cytoplasmatic circRNA and its depletion in alveolar rhabdomyosarcoma cells impacts cell homeostasis favouring cell migration, pointing to this non-coding RNA as a novel regulator of the alveolar rhabdomyosarcoma progression and as a putative future therapeutic target.

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