Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic study of G-1 treatment on GBM cells

ABSTRACT: Transcriptomic study of G-1 treatment on GBM cells

PROVIDER: PRJNA885823 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Transcriptomic analysis of pre- and post-treatment GBM tumors (GBM-28 vs. GBM-37)

Project description:Transcriptomic analysis of pre- and post-treatment GBM tumors (GBM-28 vs. GBM-37)

| PRJNA666454 | ENA

Transcriptomic study of G-1 treatment on GBM cells

Project description:Gene expression profile analysis allowed to clarify the G-1 mechanisms of action in GBM cells.

2022-11-17 | GSE214533 | GEO

Transcriptomic analysis of pre- and post-treatment GBM tumors (GBM-28 vs. GBM-37)

Project description:Finding a novel prognostic marker and therapeutic target for aggressive GBM is necessary. By analyzing pre- and post-treatment tumors from a GBM patient who experienced a very aggressive tumor recurrence after receiving concurrent chemoradiotherapy with temozolomide, we discovered a novel prognostic marker for aggressive mesenchymal GBM

2025-05-31 | GSE158772 | GEO

Transcriptomic study of the HT22 cells after OGD treatment.

Project description:Transcriptomic study of the HT22 cells after OGD treatment.

| PRJNA741816 | ENA

Transcriptomic characterization of GBM tumor and vascular cells

Project description:Transcriptomic characterization of GBM tumor and vascular cells

| PRJNA776836 | ENA

GBM-37 (post-treatment tumor): control siRNA vs. NUPR1v.1 siRNA Transfected

Project description:Comparing the transcriptomic profiles of GBM-37 cells treated with control and NUPR1 v.1 siRNA. Goal was to examine the effects of NUPR1 v.1 on malignant mesenchymal transformation of GBM tumor after conventional treatment

2025-05-31 | GSE158774 | GEO

Transcriptomic analysis of Glioblastoma Multiform (GBM) neurospheres treated with BMI1 inhibitors.

Project description:This study is designed to decipher the early transcriptomic events upon BMI1 inhibition in the GBM.

2019-12-02 | GSE136829 | GEO

RNA-sequencing Analysis of GBM Neurosphere Cells with Fluoxetine or DMSO treatment

Project description:To determine fluoxetine-induced transcriptional signatures in GBM cancer cells, we performed RNA-sequencing analysis of three GBM patient-derived neurosphere cancer cell lines after fluoxetine or DMSO treatment. Genes with differential expression and associated transcriptional signatures were analyzed and identified in three cancer cell lines.

2021-10-24 | GSE158674 | GEO

Single RNA-Seq on GBM cells from human GBM sample

Project description:Glioblastoma multiforme (GBM), a highly malignant and heterogeneous brain tumor, contains various types of tumor and non-tumor cells. Whether GBM cells can trans-differentiate into non-neural cell types, including mural cells or endothelial cells, to support tumor growth and invasion remains controversial. Here we generated two genetic GBM models de novo in immunocompetent mouse brains, mimicking essential pathological and molecular features of human GBMs. Single-cell RNA sequencing showed that patterns of copy-number variations (CNVs) of mural cells and endothelial cells were distinct from those of GBM cells, indicating discrete origins of GBM cells and vascular components. Furthermore, lineage tracing and transplantation studies demonstrated that, although blood vessels in GBM brains underwent drastic remodeling, GBM cells did not give rise to non-neural cell types in the brain. Intriguingly, GBM cells could randomly express mesenchymal markers, including those for mural cells, during gliomagenesis. Most importantly, single-cell CNV analysis of human GBM specimens also strongly suggested that GBM cells and vascular cells are separate lineages. Instead, non-neural cell types expanded by proliferation during tumorigenesis. Therefore, cross-lineage trans-differentiation of GBM cells is very unlikely to occur during gliomagenesis. Our findings advance understanding of cell lineage dynamics during gliomagenesis, and have implications for targeted treatment of GBMs.

2025-06-19 | GSE199595 | GEO

Single RNA-Seq on GBM cells from human GBM sample

Project description:Single RNA-Seq on GBM cells from human GBM sample

| PRJNA820777 | ENA