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Coordination of widespread transcription at enhancers and target genes through BRD4 (His-NET-Seq)

ABSTRACT: Coordination of widespread transcription at enhancers and target genes through BRD4 (His-NET-Seq)

PROVIDER: PRJNA886066 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21776478.fastq.gz	Fastqsanger.gz
	SRR21776479.fastq.gz	Fastqsanger.gz
	SRR21776480.fastq.gz	Fastqsanger.gz
	SRR21776481.fastq.gz	Fastqsanger.gz
	SRR21776482.fastq.gz	Fastqsanger.gz

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Coordination of widespread transcription at enhancers and target genes through BRD4 (His-NET-Seq)

Project description:Gene transcription by RNA polymerase II (Pol II) is under the control of promoters and distal regulatory elements known as enhancers. Enhancers are themselves transcribed by Pol II which correlates with their activity. How enhancer transcription is regulated and coordinated with transcription at target genes has remained unclear. Here, we developed a high-sensitive native elongating transcript sequencing approach, called HiS-NET-seq, to provide an extended high-resolution view on transcription, especially at lowly transcribed regions such as enhancers. HiS-NET-seq uncovers new transcriptional enhancers in human cells. An integrated multi-omics analysis shows that transcription at most enhancers depends on the BET protein BRD4. We provide evidence for a direct BRD4-mediated coupling of Pol II transcription at enhancers and target genes. Specifically, BRD4 links elongation activation at enhancers and genes by maintaining their proximity. These studies reveal that transcription at enhancers and target genes is coordinated at the level of elongation.

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Coordination of widespread transcription at enhancers and target genes through BRD4 (HiChIP)

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Coordination of widespread transcription at enhancers and target genes through BRD4 (ChIP-Rx)

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Coordination of widespread transcription at enhancers and target genes through BRD4

Project description:Coordination of widespread transcription at enhancers and target genes through BRD4

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Coordination of widespread transcription at enhancers and target genes through BRD4 (HiChIP)

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Project description:Coordination of widespread transcription at enhancers and target genes through BRD4 (ChIP-Rx)

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A BRD4-mediated elongation control point primes transcribing RNA polymerase II for 3'-processing and termination [NET-seq]

Project description:In this study, we reveal that BRD4 underlies a general 5'-elongation checkpoint that primes transcribing RNA polymerase II for 3'-RNA processing and transcription termination. BRD4-specific degradation impairs Pol II pause release, induces massive readthrough transcription, and RNA cleavage defects. Acute loss of BRD4 disrupts the recruitment of 3'-RNA processing factors.

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Coordination of widespread transcription at enhancers and target genes through BRD4

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-07-06 | GSE214594 | GEO