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Role of Caveolin 1 in metabolic programming of fetal brain

ABSTRACT: Role of Caveolin 1 in metabolic programming of fetal brain

PROVIDER: PRJNA887034 | ENA |

REPOSITORIES: ENA

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Role of Caveolin 1 in metabolic programming of fetal brain (bulk RNA-seq data)

Project description:Role of Caveolin 1 in metabolic programming of fetal brain (bulk RNA-seq data)

| PRJNA888986 | ENA

Role of Caveolin 1 in metabolic programming of fetal brain

Project description:Caveolae are plasma membrane invaginations found in most cells of mammals. Caveolin-1 (Cav1) encodes a major protein of the lipid rafts of these membrane structures. Cav1-null mice, though viable, show various phenotypic defects. At an early adult age, these mice show brain aging that resemble brain of one and half year old wildtype mice, and exhibit symptoms that are hallmarks of Alzheimer’s disease. It is not known if the ablation of Cav1 in these mice impacts the brain at the fetal stage that then influences brain function later in life. Single nuclei RNA sequencing was performed with fetal brain of wildtype and Cav1 knockout mice. Results showed that specific metabolism genes were differentially expressed bewteen different glial cells.

2023-09-20 | GSE214759 | GEO

Role of Caveolin 1 in metabolic programming of fetal brain (bulk RNA-seq data)

Project description:Caveolae are plasma membrane invaginations found in most cells of mammals. Caveolin-1 (Cav1) encodes a major protein of the lipid rafts of these membrane structures. Cav1-null mice, though viable, show various phenotypic defects. At an early adult age, these mice show brain aging that resemble brain of one and half year old wildtype mice, and exhibit symptoms that are hallmarks of Alzheimer’s disease. It is not known if the ablation of Cav1 in these mice impacts the brain at the fetal stage that then influences brain function later in life. RNA-seq was performed to profile gene expression of fetal brain (gestation day 15) and aging brain (week 70) of Cav1 knockout mice. The data was comapred with genes expression data of fetal brain (gestation day 15) and aging brain (week 70) of wildtype mice from our earlier study.

2023-09-20 | GSE215139 | GEO

Fetal programming of muscle transcriptome in response to gestational dietary protein levels in the pig

Project description:This SuperSeries is composed of the following subset Series: GSE33737: Fetal programming of muscle transcriptome in response to gestational dietary protein levels in the pig [AP] GSE33738: Fetal programming of muscle transcriptome in response to gestational dietary protein levels in the pig [HP] GSE33739: Fetal programming of muscle transcriptome in response to gestational dietary protein levels in the pig [LP] Refer to individual Series

2012-09-05 | E-GEOD-33740 | biostudies-arrayexpress

Fetal programming of hepatic transcriptome in response to gestational dietary protein levels in the pig

Project description:This SuperSeries is composed of the following subset Series: GSE25482: Fetal programming of hepatic transcriptome in response to gestational dietary protein levels in the pig (AP data set) GSE25483: Fetal programming of hepatic transcriptome in response to gestational dietary protein levels in the pig (HP data set) Refer to individual Series

2011-11-30 | E-GEOD-25484 | biostudies-arrayexpress

Fetal liver programming induced by placental endocrine malfunction

Project description:Fetal liver programming induced by placental endocrine malfunction

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Expression data from 15 month old rat brain subjected to fructose fetal programming

Project description:Fructose has recently been observed to affect brain metabolism and cognitive function in adults. However, possible fetal programming of brain metabolism induced by gestational fructose has not been examined. We evaluated mitochondrial function in the brain of aging (15 month) male offspring of Fischer F344 rat dams fed either a high-fructose diet (50% energy from fructose) or a matched control diet during early life (gestation and lactation). We used microarrays to detail changes in global programme of gene expression in offspring brains from rats subjected to either a control diet or a high fructose diet during gestation and lactation

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Fetal liver programming induced by placental endocrine malfunction

Project description:The placenta acts as an interface between the mother and fetus, regulating nutrient transport and secreting hormones which impact maternal metabolism. Complications during pregnancy, such as placental endocrine malfunction, programme offspring to develop metabolic disease during adulthood, in part via changes in gene expression in critical metabolic organs, such as the liver, during fetal development. Placental endocrine malfunction was induced via the misexpression of two imprinted genes (Igf2 and H19) exclusively in the endocrine zone of the mouse placenta, to study the consequences this has on fetal hepatic gene expression.

2023-11-30 | E-MTAB-11457 | biostudies-arrayexpress

Caveolin-1 Knockout Hearts

Project description:Hearts Lacking Caveolin-1 Develop Hypertrophy with Normal Cardiac Substrate Metabolism Keywords: gene knockout

2009-03-04 | GSE10849 | GEO

Epigenetic extinction of fetal programming promotes leukemia stem cell activity

Project description:Epigenetic extinction of fetal programming promotes leukemia stem cell activity

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