Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Inhibition of LIFR blocks adiposity driven endometrioid endometrial cancer growth

ABSTRACT: Inhibition of LIFR blocks adiposity driven endometrioid endometrial cancer growth

PROVIDER: PRJNA887435 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Inhibition of LIFR blocks adiposity driven endometrioid endometrial cancer growth

Project description:We examined the mechanisms by which adiposity regulates EEC progression. EEC cells were incubated with or without adipocyte conditioned medium (ADP-CM), and total RNA was isolated for RNA-seq analysis. Our results demonstrated that ADP-CM stimulated EEC cells showed upregulation of several LIF/LIFR modulated pathways including Jak/STAT and cytokine pathways.

2022-11-16 | GSE214872 | GEO

Adipocyte induced distinct gene expression profiling of human endometrioid endometrial cancer cells upon SIRT1 inhibition.

Project description:We examined the mechanism by which adiposity regulates endometrioid endometrial cancer progression. Ishikawa EEC cells were co-cultured with mature adipocytes in presence or absence of SIRT1 inhibitor EX527, and total RNA was isolated for RNA-seq analysis and focus on the functional relevance that adipocyte co-culture affected pathways and related biomarkers may have in endometrial cancer response to adiposity.

2024-08-05 | GSE272263 | GEO

Epigenome analysis of endometrial endometrioid adenocarcinoma tissues

Project description:We performed genome-wide DNA methylation profiling of endometrial endometrioid adenocarcinoma tissues derived from patients in the Cancer Institute Hospital of Japanese Foundation for Cancer Research.

2019-09-13 | GSE136791 | GEO

Epigenome analysis of precursor lesions of endometrial endometrioid carcinoma.

Project description:We performed genome-wide DNA methylation profiling of precursor lesions of endometrial endometrioid carcinoma tissues derived from patients in the Cancer Institute Hospital of Japanese Foundation for Cancer Research.

2024-02-26 | GSE243303 | GEO

EMca: serous, endometrioid, normal (miRNA)

Project description:To determine the expression profiles of microRNAs (miRNAs) and to examine specific miRNA expression in endometrial serous adenocarcinoma in comparison with normal endometrial tissue and endometrial endometrioid adenocarcinoma.　Twenty-one serous adenocarcinoma tissues, 20 endometrioid adenocarcinoma tissues, and 7 normal endometrial tissues were enrolled.　miRNA expression profiles were examined using miRNA microarray.

2018-11-01 | GSE25405 | GEO

Epigenome analysis of endometrial endometrioid adenocarcinoma tissues

Project description:Epigenome analysis of endometrial endometrioid adenocarcinoma tissues

| PRJNA563677 | ENA

Genome-wide DNA methylation profiles of endometrioid endometrial cancer tissue

Project description:Genome-wide DNA methylation screening was performed using the Infinium MethylationEPIC BeadChip in 49 fresh-frozen tissue samples and 31 formalin-fixed paraffin-embedded tissue samples obtained from surgically resected materials of patients with endometrioid endometrial cancer.

2022-11-09 | GSE178610 | GEO

Adiposity alters protective mechanisms of progesterone through dysregulation of endometrial metallothionein expression

Project description:In this study, we sought to understand the effects of excess adipose on the benign endometrium. We used a physiologic in vitro coculture system consisting of multicellular organoids of the benign human endometrium and adipose spheroids in the presence of estradiol, progesterone, and testosterone to mimic the menstrual cycle. Gene expression analysis of endometrial organoids under high adiposity conditions revealed downregulation of genes normally expressed in secretory endometrium, suggestive of an altered progesterone response. Genes associated with ion homeostasis and detoxification of reactive oxygen species were also downregulated, including the metallothionein (MT) family of genes. We demonstrated that MT gene expression in endometrial organoids was regulated by progesterone specifically in the epithelial cells, and that progesterone receptor is recruited to the promoters of MT genes in endometrial epithelial cells. We illustrated the impact of MT dysregulation by silencing MT genes in endometrial epithelial cells, resulting in increased DNA damage. Our results reveal that exposing the endometrium to high adiposity can compromise the protective effects of progesterone, dysregulate MT genes in the endometrial epithelium, and leave the endometrium vulnerable to ROS-induced DNA damage.

2024-04-19 | GSE240926 | GEO

Epigenome analysis of precursor lesions of endometrial endometrioid carcinoma.

Project description:Epigenome analysis of precursor lesions of endometrial endometrioid carcinoma.

| PRJNA1017682 | ENA

Genome-wide DNA methylation profiles of endometrioid endometrial cancer tissue

Project description:Genome-wide DNA methylation profiles of endometrioid endometrial cancer tissue

| PRJNA739717 | ENA