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Role of Caveolin 1 in metabolic programming of fetal brain (bulk RNA-seq data)

ABSTRACT: Role of Caveolin 1 in metabolic programming of fetal brain (bulk RNA-seq data)

PROVIDER: PRJNA888986 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21851154_1.fastq.gz	Fastqsanger.gz
	SRR21851154_2.fastq.gz	Fastqsanger.gz
	SRR21851155_1.fastq.gz	Fastqsanger.gz
	SRR21851155_2.fastq.gz	Fastqsanger.gz
	SRR21851156_1.fastq.gz	Fastqsanger.gz

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Role of Caveolin 1 in metabolic programming of fetal brain

Project description:Role of Caveolin 1 in metabolic programming of fetal brain

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Role of Caveolin 1 in metabolic programming of fetal brain (bulk RNA-seq data)

Project description:Caveolae are plasma membrane invaginations found in most cells of mammals. Caveolin-1 (Cav1) encodes a major protein of the lipid rafts of these membrane structures. Cav1-null mice, though viable, show various phenotypic defects. At an early adult age, these mice show brain aging that resemble brain of one and half year old wildtype mice, and exhibit symptoms that are hallmarks of Alzheimer’s disease. It is not known if the ablation of Cav1 in these mice impacts the brain at the fetal stage that then influences brain function later in life. RNA-seq was performed to profile gene expression of fetal brain (gestation day 15) and aging brain (week 70) of Cav1 knockout mice. The data was comapred with genes expression data of fetal brain (gestation day 15) and aging brain (week 70) of wildtype mice from our earlier study.

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Role of Caveolin 1 in metabolic programming of fetal brain

Project description:Caveolae are plasma membrane invaginations found in most cells of mammals. Caveolin-1 (Cav1) encodes a major protein of the lipid rafts of these membrane structures. Cav1-null mice, though viable, show various phenotypic defects. At an early adult age, these mice show brain aging that resemble brain of one and half year old wildtype mice, and exhibit symptoms that are hallmarks of Alzheimer’s disease. It is not known if the ablation of Cav1 in these mice impacts the brain at the fetal stage that then influences brain function later in life. Single nuclei RNA sequencing was performed with fetal brain of wildtype and Cav1 knockout mice. Results showed that specific metabolism genes were differentially expressed bewteen different glial cells.

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Role of caveolin-1 in metabolic programming of fetal brain.

Project description:Mice lacking caveolin-1 (Cav1), a key protein of plasma membrane, exhibit brain aging at an early adult stage. Here, integrative analyses of metabolomics, transcriptomics, epigenetics, and single-cell data were performed to test the hypothesis that metabolic deregulation of fetal brain due to the ablation of Cav1 is linked to brain aging in these mice. The results of this study show that lack of Cav1 caused deregulation in the lipid and amino acid metabolism in the fetal brain, and genes associated with these deregulated metabolites were significantly altered in the brain upon aging. Moreover, ablation of Cav1 deregulated several metabolic genes in specific cell types of the fetal brain and impacted DNA methylation of those genes in coordination with mouse epigenetic clock. The findings of this study suggest that the aging program of brain is confounded by metabolic abnormalities in the fetal stage due to the absence of Cav1.

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