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Identification of circular RNAs in amyotrophic lateral sclerosis I

ABSTRACT: Identification of circular RNAs in amyotrophic lateral sclerosis I

PROVIDER: PRJNA889852 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21882920_1.fastq.gz	Fastqsanger.gz
	SRR21882920_2.fastq.gz	Fastqsanger.gz
	SRR21882921_1.fastq.gz	Fastqsanger.gz
	SRR21882921_2.fastq.gz	Fastqsanger.gz
	SRR21882922_1.fastq.gz	Fastqsanger.gz

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Identification of circular RNAs in amyotrophic lateral sclerosis

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Project description:Circular RNAs are abundant, covalently closed transcripts that arise in cells through back-splicing and display distinct expression patterns across cells and developmental stages. While their functions are largely unknown, their intrinsic stability has made them valuable biomarkers in diseases like cancer. Here, we set out to examine circRNA patterns in amyotrophic lateral sclerosis (ALS). By RNA-sequencing analysis, we first identified circRNAs and linear RNAs that were differentially abundant in skeletal muscle biopsies from ALS and normal individuals. Among these, 8 circRNAs were significantly elevated and 10 significantly reduced in ALS, while the linear counterparts, arising from shared precursor RNAs, did not change. Several of these circRNAs were also differentially abundant in motor neurons derived from human induced pluripotent stem cells (iPSCs) bearing ALS mutations, and across different disease stages in skeletal muscle from a mouse model of ALS (SOD1G93A). Interestingly, several of the circRNAs significantly elevated in muscle were significantly reduced in the spinal cord from ALS patients and ALS (SOD1G93A) mice. In sum, we have identified differentially abundant circRNAs in ALS-relevant tissues (muscle and spinal cord) that could inform about neuromuscular molecular programs in ALS and guide the development of therapies.

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