Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic characterization of FLC-mutant engineered human hepatocyte organoids

ABSTRACT: Transcriptomic characterization of FLC-mutant engineered human hepatocyte organoids

PROVIDER: PRJNA890609 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR21904220_1.fastq.gz	Fastqsanger.gz
	SRR21904220_2.fastq.gz	Fastqsanger.gz
	SRR21904221_1.fastq.gz	Fastqsanger.gz
	SRR21904221_2.fastq.gz	Fastqsanger.gz
	SRR21904222_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 98

Similar Datasets

Transcriptomic characterization of FLC-mutant engineered human hepatocyte organoids

Project description:We engineered human hepatocyte organoids to study the effect of different fibrolamellar carcinoma mutations. To study the effects and differences between the different mutations, we performed bulk RNA-sequencing to understand the transcriptomic changes.

2023-03-15 | GSE215785 | GEO

Generation and characterization of mature hepatocyte organoids for liver metabolic studies

Project description:The liver plays a central role in whole body metabolic regulation. Studies of liver metabolism are mostly done in vivo in animal models due to the lack of reliable in vitro systems that can recapitulate liver metabolic functions and their regulation. Hepatocyte organoids (HOs) generated in vitro recently are powerful tools for liver regeneration. Here we developed a novel culture condition that enabled successful generation of mature hepatocyte organoids (MHOs) with metabolic functions characteristic of adult livers. We showed that the MHOs can be used to study gene expression that exhibit zonal patterns in vivo, hepatic proliferation during tumorigenesis and metabolic alterations in disorders of both alcoholic and non-alcoholic fatty liver diseases.

2024-05-15 | GSE245632 | GEO

Flower development FRI/FLC

Project description:Arabiposis plants with conbinations of different FRIGIDA (FRI) and FLOWERING LOCUS C (FLC) alleles grown in short days (9L:15D) for 30 days at 21°C, then shifted to long days (16L:8D). Genotypes: Columbia wild type (Col-0): fri FLC Columbia with introgressed FRI from Sf-2: FRI FLC Columbia with introgressed FRI and deleted FLC (flc-3): FRI flc Columbia with deleted FLC (flc-3): fri flc Time points: 0, 2, and 4 days after shift to long days Keywords = flowering Keywords: time-course

2003-08-06 | GSE577 | GEO

Comprehensive gene expression analysis of grape-like and other morphologically different organoids in iPSC derived hepatocyte organoids(iHOs).

Project description:iHOs contain morphologically different organoids. Comprehensive gene expression analysis showed grape-like organoids have hepatocyte-like gene expression profiles.

2024-11-18 | GSE248439 | GEO

Single-cell RNA-seq of engineered healthy human kidney organoids

Project description:Single-cell RNA-seq of engineered healthy human kidney organoids. These data are part of a larger investigation (data not provided here) showing that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids which can be inhibited by human recombinant soluble ACE2 (hrsACE2), demonstrating that hrsACE2 can significantly block early stages of SARS-CoV-2 infections.

2020-04-05 | GSE147863 | GEO

RNA sequencing of CRC tumor organoids engineered with key driver mutations

Project description:We profiled CRC organoids engineered with different combinations of driver mutations. All organoids were derived from one mouse and then mutations were sequentially introduced by CRISPR Cas9

2022-09-16 | GSE207668 | GEO

Generation and characterization of mature hepatocyte organoids for liver metabolic studies

Project description:Generation and characterization of mature hepatocyte organoids for liver metabolic studies

| PRJNA1029192 | ENA

Transcription profiling of Arabidopsis plants of three different genotypes (FRI FLC, FRI flc and fri flc) induced to flowering by shifting from short day conditions to long day conditions

Project description:Plants of three different genotypes (FRI FLC, FRI flc and fri flc) were induced to flowering by shifting from short day conditions to long day conditions. FRI=FRIGIDA, FLC=FLOWERING LOCUS C.

2005-09-08 | E-TABM-19 | biostudies-arrayexpress

Genetically engineered endothelial niche induces vascularization in human kidney organoids

Project description:Here we developed a method to incorporate a genetically engineered endothelial niche into an established protocol for generating human kidney organoids.

2023-05-22 | GSE232767 | GEO

Small RNA-sequencing of primary fibrolamellar carcinoma (FLC), FLC patient-derived xenograft, and maturational liver lineage stages

Project description:Fibrolamellar carcinoma (FLC) is a rare liver cancer. Here we characterized the small RNA expression landscape of primary FLC, a FLC patient-derived xenograft model, and normal maturational liver lineage stages

2019-03-07 | GSE114974 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data