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Gamma entrainment using sensory stimuli alleviate chemo brain pathology and cognitive impairment induced by chemotherapy agents

ABSTRACT: Gamma entrainment using sensory stimuli alleviate chemo brain pathology and cognitive impairment induced by chemotherapy agents

PROVIDER: PRJNA892229 | ENA |

REPOSITORIES: ENA

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Gamma entrainment using sensory stimuli alleviate chemo brain pathology and cognitive impairment induced by chemotherapy agents

Project description:We are using scRNA-seq to analyze how 40 Hz sensory stimulation can modulate chemo brain pathology in mouse hippocampus.

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Differential gene expression of K. aerogenes during temperature entrainment

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Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents.

Project description:A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of doxorubicin proved to be a rapid precision guided cancer-killing module. The multi-stimuli, i.e., pH-, thermo- and photo-responsive drug release behavior of the nanoconjugates opens up a wider corridor for on-demand triggered drug administration. The simple synthesis protocol, combined with the multitudes of interesting features packed into a single nanoformulation, clearly demonstrates the competing role of this Cu2S nanosystem in future cancer treatment strategies.

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Chemo-senolytic therapeutic potential against angiosarcoma

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Differential gene expression of K. aerogenes during temperature entrainment

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Entrainment of Breast Cell Lines Results in Rhythmic Fluctuations of MicroRNAs

Project description:Circadian rhythms are essential for temporal (~24 h) regulation of molecular processes in diverse species. Dysregulation of circadian gene expression has been implicated in the pathogenesis of various disorders, including hypertension, diabetes, depression, and cancer. Recently, microRNAs (miRNAs) have been identified as critical modulators of gene expression post-transcriptionally, and perhaps involved in circadian clock architecture or their output functions. The aim of the present study is to explore the temporal expression of miRNAs among entrained breast cell lines. For this purpose, we evaluated the temporal (28 h) expression of 2006 miRNAs in MCF-10A, MCF-7, and MDA-MB-231 cells using microarrays after serum shock entrainment. We noted hundreds of miRNAs that exhibit rhythmic fluctuations in each breast cell line, and some of them across two or three cell lines. Afterwards, we validated the rhythmic profiles exhibited by miR-141-5p, miR-1225-5p, miR-17-5p, miR-222-5p, miR-769-3p, and miR-548ay-3p in the above cell lines, as well as in ZR-7530 and HCC-1954 using RT-qPCR. Our results show that serum shock entrainment in breast cells lines induces rhythmic fluctuations of distinct sets of miRNAs, which have the potential to be related to endogenous circadian clock, but extensive investigation is required to elucidate that connection.

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Gene expression of yeast fermentor culture after circadian temperature entrainment

Project description:Gene expression of yeast fermentor culture after circadian temperature entrainment

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Gamma entrainment binds higher order brain regions and alleviates neurodegeneration

Project description:Gamma entrainment binds higher order brain regions and alleviates neurodegeneration

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Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization

Project description:In this study, we have shown how ZMYND8, a putative chromatin reader, chemosensitizes, chemo-resistant breast cancer cells, by modulating poised oncogenes.

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