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Transcriptomic analysis of the livers of mice acutely challenge with IL1B

ABSTRACT: Transcriptomic analysis of the livers of mice acutely challenge with IL1B

PROVIDER: PRJNA892922 | ENA |

REPOSITORIES: ENA

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Transcriptomic analysis of the livers of mice acutely challenge with IL1B

Project description:Livers from mice subjected to a single IL1B injection were collected and used to prepare RNA for transcriptomics analysis.

2023-06-29 | GSE216278 | GEO

A chromatin-regulated biphasic circuit coordinates IL1B-mediated inflammation

Project description:Inflammation is characterized by a biphasic cycle consisting initially of a pro-inflammatory phase which is subsequently resolved by anti-inflammatory processes. The coordination of these two disparate states needs to be highly controlled, suggesting that the regulation of the cytokines that drive these processes are intimately linked. Interleukin-1 beta (IL1B) is a master regulator of pro-inflammation and is encoded within the same topologically associated domain (TAD) as interleukin-37 (IL37). IL37 has recently emerged as a powerful anti-inflammatory cytokine which diametrically opposes the function of IL1B. Within this TAD, we identified a novel long non-coding RNA called AMANZI which negatively regulates IL1B expression and trained immunity through the induction of IL37 transcription. We found that the activation of IL37 occurs through the formation of a dynamic long-range chromatin contact that leads to the temporal delay of anti-inflammatory responses. The common variant rs16944 present in AMANZI augments this regulatory circuit, predisposing individuals to enhanced pro-inflammation or immunosuppression. Our work illuminates a chromatin-mediated biphasic circuit coordinating expression of IL1B and IL37, thereby regulating two functionally opposed states of inflammation from within a single TAD.

2023-10-27 | PXD045971 | Pride

Bekkar2018 - IL1B secretion and regulation in atherosclerosis

Project description:This network was obtained by combining (with an OR logical operator) the following list of IL1B_secretion activators: TXNIP AND IL1B - reference in pubmed:23747245 IL1B AND hydrogen_peroxide - reference in pubmed:20023662 NLRP3_PYCARD_CASP1_complex AND IL1B AND cholesterol_crystal - reference in pubmed:23747245 IL1B AND NLRP3 AND hydrogen_peroxide - reference in pubmed:20023662 IL1B AND oxLDL AND TLR4 - reference in pubmed:23812099 IL1B AND glucose - reference in pubmed:20023662 IL1B AND IL1B_secretion - reference in pubmed:23747245 IL1B AND CASP8 - reference in pubmed:22365665 NLRP3_PYCARD_CASP1_complex AND NFE2L2 AND IL1B - reference in pubmed:23747245 PYCARD AND IL1B AND hydrogen_peroxide - reference in pubmed:20023662 IL1B AND NLRP3 AND glucose - reference in pubmed:20023662 NFE2L2 AND IL1B - reference in pubmed:23747245 IL1B AND mitochondrial_respiratory_chain_complex_I - reference in pubmed:21124315 TXNIP AND IL1B AND glucose - reference in pubmed:20023662 IL1B AND oxLDL AND CD36 - reference in pubmed:23812099 IL1B AND ripoptosome - reference in pubmed:22365665 NLRP3_PYCARD_CASP1_complex AND IL1B - reference in pubmed:23747245

2018-11-16 | MODEL1712240002 | BioModels

Il1b

Project description:Rattus norvegicus Il1b, interleukin 1 beta [Source:RGD Symbol;Acc:2891], is expressed in 4 baseline experiment(s);

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Il1b

Project description:Rattus norvegicus Il1b, interleukin 1 beta [Source:RGD Symbol;Acc:2891], is differentially expressed in 28 experiment(s);

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Chromatin IP sequencing of the nuclear factor HMGB1 in livers from mice after a metabolic stress either induced by a 12-week high fat diet consumption or a fasting (6hours)-refeeding (8hours) challenge.

Project description:To unveil HMGB1 DNA occupancy in livers of mice after a metabolic stress either induced by a 12-week high fat diet consumption or a fasting (6hours)-refeeding (8hours) challenge. Challenges known to generate a robust activation of hepatic lipogenesis and liver steatosis.

2022-03-31 | E-MTAB-11543 | biostudies-arrayexpress

A proteomic analysis of livers from RagAGTP mice

Project description:A proteomic analysis of livers from RagAGTP/ TSC-KO mice

2021-06-21 | PXD023735 | Pride

Gene expression data of C57BL/6, Il1a-knockout and Il1b-knockout mice at 24 hours after spinal cord injury

Project description:We have previously shown that Il1a-knockout (KO) mice exhibit rapid (at day 1) and persistent improvements in locomotion associated with reduced lesion volume compared with Il1b-KO mice and C57BL/6 controls after traumatic spinal cord injury (SCI). To investigate the mechanism by which Il1a mediates its detrimental effect, we analyzed the transcriptome of the injured spinal cord of Il1a-KO, Il1b-KO and C57BL/6 mice at 24 hours after SCI using GeneChip microarrays. Il1a-KO, Il1b-KO and C57BL/6 mice were subjected to a 50-kdyn SCI and a 6-mm spinal cord segment centered over the site of contusion extracted for RNA isolation and microarray analysis.

2015-06-27 | E-GEOD-70302 | biostudies-arrayexpress

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Project description:Oryctolagus cuniculus IL1B, interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992], is expressed in 1 baseline experiment(s);

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