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ABSTRACT: Akk blunts Colorectal Cancer related to Hspa1 _Mouse cells

PROVIDER: PRJNA893182 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22012670_1.fastq.gz	Fastqsanger.gz
	SRR22012670_2.fastq.gz	Fastqsanger.gz
	SRR22012671_1.fastq.gz	Fastqsanger.gz
	SRR22012671_2.fastq.gz	Fastqsanger.gz
	SRR22012672_1.fastq.gz	Fastqsanger.gz

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Project description:Akkermansia muciniphila (Akk) associated with multiple metabolic diseases and administration of Akk can improve the metabolic disorders. However, little is known about the effect of Akk on jejunal epithelial cells which absorb lipid and interact with oral administrated Akk. We oral administrated Akk to mice and measured the lipid absorption and gene expression in small intestinal epithelial cells. The long-term effect of Akk treatment reduced lipid deposits in the liver and adipocytes with improved the glucose metabolism. This is particularly caused by reduced lipid absorption in jejunal epithelia. Akk feeding reduced the expression of those genes that regulate synthesis and cell cycles, characters of the host cell responding to energy deficiency. In fact, we detected increased AMPK-alpha phosphorylation levels in Akk-treated jejunal epithelial cells both in vivo and in vitro. Furthermore, activating AMPK inhibits lipids absorption in jejunum. Thus, we conclude that oral administration of Akk activates the AMPK pathway and represses the lipid absorption in jejunal epithelial cells, which contributes to the metabolic benefits of oral Akk administration.

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Genome-wide maps of SOX9 binding sites in human colorectal cancer cells

Project description:Aberrant expression of SOX9 in human colorectal cancer cells suggests its roles in the development of colorectal cancer. To gain insight into SOX9-mediated transcriptional regulation in colorectal cancer cells, we attempted to identify its physiological targets on a genome-scale using chromatin immunoprecipitation (ChIP) followed by sequencing (ChIP-seq) in HT-29, human colorectal cancer cells. SOX9 CHIP-seq was carried out using HT-29 cells.

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