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ABSTRACT: Akk blunts Colorectal Cancer related to Hspa1 _Mouse cells

PROVIDER: PRJNA893182 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22012670_1.fastq.gz	Fastqsanger.gz
	SRR22012670_2.fastq.gz	Fastqsanger.gz
	SRR22012671_1.fastq.gz	Fastqsanger.gz
	SRR22012671_2.fastq.gz	Fastqsanger.gz
	SRR22012672_1.fastq.gz	Fastqsanger.gz

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Project description:Akk blunts Colorectal Cancer related to Hspa1

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Project description:Akk blunts Colorectal Cancer related to Hspa1_Mouse feces

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Akkermansia muciniphila reduces lipid absorption through activating AMPK in the jejunum

Project description:Akkermansia muciniphila (Akk) associated with multiple metabolic diseases and administration of Akk can improve the metabolic disorders. However, little is known about the effect of Akk on jejunal epithelial cells which absorb lipid and interact with oral administrated Akk. We oral administrated Akk to mice and measured the lipid absorption and gene expression in small intestinal epithelial cells. The long-term effect of Akk treatment reduced lipid deposits in the liver and adipocytes with improved the glucose metabolism. This is particularly caused by reduced lipid absorption in jejunal epithelia. Akk feeding reduced the expression of those genes that regulate synthesis and cell cycles, characters of the host cell responding to energy deficiency. In fact, we detected increased AMPK-alpha phosphorylation levels in Akk-treated jejunal epithelial cells both in vivo and in vitro. Furthermore, activating AMPK inhibits lipids absorption in jejunum. Thus, we conclude that oral administration of Akk activates the AMPK pathway and represses the lipid absorption in jejunal epithelial cells, which contributes to the metabolic benefits of oral Akk administration.

2025-01-25 | GSE254234 | GEO

Project description:OVOL2 alteration related transcriptome sequencing in colorectal cancer cells

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Intestinal Akkermansia muciniphila complements the therapeutic efficacy of PD1 therapy by reshaping the immunosuppressive microenvironment in nonalcoholic fatty liver disease (NAFLD)-induced hepatocellular carcinoma [16S]

Project description:16S rRNA sequencing showed that Akkermansia muciniphila (Akk) decreased during the course of HCC tumor development, and daily administration of Akk not only ameliorated liver steatosis and cholesterol biosynthesis but also effectively attenuated the development of NAFLD-induced HCC.

2024-11-29 | GSE242468 | GEO

Genome-wide maps of SOX9 binding sites in human colorectal cancer cells

Project description:Aberrant expression of SOX9 in human colorectal cancer cells suggests its roles in the development of colorectal cancer. To gain insight into SOX9-mediated transcriptional regulation in colorectal cancer cells, we attempted to identify its physiological targets on a genome-scale using chromatin immunoprecipitation (ChIP) followed by sequencing (ChIP-seq) in HT-29, human colorectal cancer cells. SOX9 CHIP-seq was carried out using HT-29 cells.

2015-06-08 | E-GEOD-63629 | biostudies-arrayexpress

Colorectal Cancer Cells

Project description:Colorectal Cancer Cells

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Differentially expressed miRNAs in TGF-β1-knock down human colorectal cancer cell lines vs controls

Project description:To investigate the role of TGF-β1-regulated miRNAs in the progression of colorectal cancer,we performed comprehensive miRMA microarray analysis on RNA derived from typical human colorectal cancer cell lines and TGF-β1 knock-down human colorectal cancer cell lines. We identified a novel set of TGF-β1-related miRNAs.

2013-12-16 | GSE53338 | GEO

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