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Deciphering m6A dynamics at single-base level during planarian anterior-posterior (AP) axis specification

ABSTRACT: Deciphering m6A dynamics at single-base level during planarian anterior-posterior (AP) axis specification

PROVIDER: PRJNA893572 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22020421_1.fastq.gz	Fastqsanger.gz
	SRR22020421_2.fastq.gz	Fastqsanger.gz
	SRR22020422_1.fastq.gz	Fastqsanger.gz
	SRR22020422_2.fastq.gz	Fastqsanger.gz
	SRR22020423_1.fastq.gz	Fastqsanger.gz

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Deciphering m6A dynamics at single-base level during planarian anterior-posterior (AP) axis specification

Project description:Background: The establishment of the anterior-posterior (A-P) axis is a crucial step during tissue repair and regeneration. Despite the association reported recently of N6-methyladenosine (m6A) with regeneration, the mechanism underlying the regulation of m6A in A-P axis specification during regeneration remains unknown. Herein, we deciphered the m6A landscape at a single-base resolution at multiple time points during A-P axis regeneration and constructed the de novo transcriptome assembly of the Dugesia japonica planarian.

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Deciphering m6A dynamics at single-base level during planarian anterior-posterior (AP) axis specification [m6A]

Project description:We accomplished the m6A landscapes at single-base resolution with multiple time-points during AP axis regeneration for planarian Dugesia japonica.

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Deciphering m6A dynamics at single-base level during planarian anterior-posterior (AP) axis specification [mRNA]

Project description:Deciphering m6A dynamics at single-base level during planarian anterior-posterior (AP) axis specification [mRNA]

| PRJNA893586 | ENA

Deciphering m6A dynamics at single-base level during planarian anterior-posterior (AP) axis specification [m6A]

Project description:Deciphering m6A dynamics at single-base level during planarian anterior-posterior (AP) axis specification [m6A]

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Deciphering m6A dynamics at single-base level during planarian anterior-posterior (AP) axis specification [mRNA]

Project description:We accomplished de novo transcriptome assembly for planarian Dugesia japonica.

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Mass Spectrometry analysis of human matched Anterior and Posterior lobes of Pituitary

Project description:This study provides a comprehensive proteomic analysis of five matched pairs of the anterior and posterior lobe of the pituitary, which was used to study the proteomic signature specific to both anterior and posterior lobes. Anterior Lobe n=5 Posterior Lobe n=5 A441 PT441 A442 PT442 A457 PT457 A459 PT459 A460 PT460

2022-12-07 | PXD030235 | Pride

Deciphering m6A dynamics at a single-base level during planarian anterior-posterior axis specification.

Project description:BackgroundThe establishment of the anterior-posterior (A-P) axis is a crucial step during tissue repair and regeneration. Despite the association reported recently of N6-methyladenosine (m6A) with regeneration, the mechanism underlying the regulation of m6A in A-P axis specification during regeneration remains unknown. Herein, we deciphered the m6A landscape at a single-base resolution at multiple time points during A-P axis regeneration and constructed the de novo transcriptome assembly of the Dugesia japonica planarian.ResultsImmunofluorescence staining and comparative analysis revealed that m6A is widespread across the planarian and dynamically regulated during regeneration along the A-P axis, exhibiting a strong spatiotemporal feature. The resulting datasets of m6A-modified genes identified 80 anterior-specific genes and 13 posterior-specific genes, respectively. In addition, we showed that YTHDC1 serves as the primary m6A reader to be involved in the m6A-mediated specification of A-P axis during regeneration in Dugesia japonica planarian.ConclusionsOur study provides an RNA epigenetic explanation for the specification of the A-P axis during tissue regeneration in planarian.

| S-EPMC10542940 | biostudies-literature

RNA sequencing of single cells from the midline posterior extremity in planarian Schmidtea mediterranea

Project description:RNA sequencing of single cells from the midline posterior tip of the tail and posterior blastema in planarian Schmidtea mediterranea identified new posterior-pole enriched genes

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RNA sequencing of pole-containing anterior tip regions in planarian Schmidtea mediterranea

Project description:RNA sequencing identified new anterior-pole enriched genes encoding transcription factors, a secreted protein, and a transmembrane protein, including NR4A, a nuclear receptor gene that is important in patterning the planarian head and tail.

2019-05-25 | GSE121045 | GEO

Single-muscle-cell transcriptome profiling along the planarian anteroposterior axis

Project description:How positional information instructs adult tissue maintenance is poorly understood. Planarians undergo whole-body regeneration and tissue turnover, providing a model for adult positional information studies. Genes encoding secreted and transmembrane components of multiple developmental pathways are predominantly expressed in planarian muscle cells. Several of these genes regulate regional identity, consistent with muscle harboring positional information. Here, single-cell RNA-sequencing of 115 muscle cells from distinct anterior-posterior regions identified 44 regionally expressed genes, including multiple Wnt and ndk/FGF receptor-like (ndl/FGFRL) genes. Two distinct FGFRL-Wnt circuits, involving juxtaposed anterior FGFRL and posterior Wnt expression domains, controlled planarian head and trunk patterning. ndl-3 and wntP-2 inhibition expanded the trunk, forming ectopic mouths and secondary pharynges, which independently extended and ingested food. fz5/8-4 inhibition, like that of ndk and wntA, caused posterior brain expansion and ectopic eye formation. Our results suggest that FGFRL-Wnt circuits operate within a body-wide coordinate system to control adult axial positioning.

2016-04-12 | GSE74360 | GEO

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