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Gene expression profile of the amygdala from WT and Sema6d-/- mice at single cell level

ABSTRACT: Gene expression profile of the amygdala from WT and Sema6d-/- mice at single cell level

PROVIDER: PRJNA893609 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22022178_1.fastq.gz	Fastqsanger.gz
	SRR22022178_2.fastq.gz	Fastqsanger.gz
	SRR22022179_1.fastq.gz	Fastqsanger.gz
	SRR22022179_2.fastq.gz	Fastqsanger.gz

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Gene expression profile of the amygdala from WT and Sema6d-/- mice at single cell level

Project description:Sema6D is highly expressed in the amygdala. We used single nucleus RNA sequencing (snRNA-seq) to analyze the roles of Sema6D in the amygdala.

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Spatial gene expression profile of the brain from WT and Sema6d-/- mice

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Estradiol-dependent gene expression profile in the amygdala of ovariectomized SHRs

Project description:Pre-menopausal women exhibit a lower arterial pressure (AP), a lower sympathetic outflow and a greater baroreceptor reflex than age-matched men. However, AP and subsequent cardiovascular diseases dramatically increases in post-menopausal women. Estrogen level is believed to play a role in the regulation of the basal blood pressure, emotion and hormonal response in the different periods of life of a woman but the molecular mechanisms are still not well understood. Amygdala is a major nucleus of the limbic system involved in the control of cardiovascular, behavior and hormonal response to stress or fear. Since variations in estrogen level are associated with cardiovascular, behavior, and hormonal response changes, we hypothesized that it could also be associated with different neuronal functions in amygdala, characterized by a differential gene expression profile. Young Female SHRs were ovariectomized (OV) and half of them received an estradiol treatment (OV+E2) for one month. We investigated whether the amygdala of ovariectomized rats exhibit gene expression differences after estradiol treatment by using microarray technique.

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Gene expression profile at single cell level of WT or flt1 mutant

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Gene expression of central amygdala of mice

Project description:Purpose: The goals of this study are to screen out the changes of gene expression profile in response to high fat diet, an mRNA-seq was performed in central amygdala Methods: 6-week-old male wild-type mice were fed with high fat diet (HFD, containing 45% fat) or normal chow diet (ND) for 5 months. And then their central amygdala tissues were removed and total RNA was extracted to perform RNA sequencing. Results:The KEGG pathway analysis showed that genes related to neuroactive ligand-receptor interaction and calcium signaling pathway were dramatically upregulated after HFD Conclusions: Our study represents the first detailed analysis of central amygdalar transcriptomes of mice subjected to high fat diet, with biologic replicates, generated by RNA-seq technology. Our results show genes related to neuroactive ligand-receptor interaction and calcium signaling pathway were dramatically upregulated after high fat diet feeding,which hint at the importance of ion channel in central amygdala after high fat feeding.

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H3K9me2 level in WT, jmj28-2.

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Sema6D reverse signaling controls lipid metabolism for macrophage polarization linking mTOR to PPARγ

Project description:Purpose: The goal of this study is to compare downstream genes of Sema6D signaling in LPS plus IFNg stimulated macrophages. Methods: Bone marrow derived macrophage mRNA profiles of 7 weeks of wild type (WT) and Sema6D-/- mice were stimulated by LPS for 4 hrs. Results: According to this comparison, we found that 550 genes were downregulated in Sema6D-/- macrophages than WT macrophages in response to LPS. Conclusions: Our study represents 62 genes were supressed in both M1 and M2 Sema6D-/- macrophage than WT macrophages, suggesting of Sema6D reverse sigaling genes.

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