Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Plasma Small Extracellular RNA as a Biomarker of Autoimmune Flairs and Beta Cell Death in Type 1 Diabetes Using Frequent Prospective Peri-Onset Sampling

ABSTRACT: Plasma Small Extracellular RNA as a Biomarker of Autoimmune Flairs and Beta Cell Death in Type 1 Diabetes Using Frequent Prospective Peri-Onset Sampling

PROVIDER: PRJNA894202 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22038232.fastq.gz	Fastqsanger.gz
	SRR22038233.fastq.gz	Fastqsanger.gz
	SRR22038234.fastq.gz	Fastqsanger.gz
	SRR22038235.fastq.gz	Fastqsanger.gz
	SRR22038236.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 412

Similar Datasets

Plasma Small Extracellular RNA as a Biomarker of Autoimmune Flairs and Beta Cell Death in Type 1 Diabetes Using Frequent Prospective Peri-Onset Sampling

Project description:We seek to discover small RNA biomarkers of autoimmune activity andor beta cell damage in type 1 diabetes. Pilot studies showed that heparinized plasma failed analyses, but that EDTA and citrated plasma did well, so 353 appropriate plasma samples average 11 per subject prospectively collected every 1 to 3 months from 32 high risk MAB or newly diabetic children and adolescents were collected, and the first 94 analyzed, for circulating small regulatory RNAs. 92 of 94 resulting cDNA libraries gave adequate numbers of miRNA mapped reads, but QC using spiked RNA internal standards showed abnormally high small RNA levels in 8 mildly hemolyzed plasma samples, leaving 84 of 94 with analyzable data. Equal numbers of EDTA and citrated plasma were analyzed successfully. Over the next period we will complete series on another 6 subjects, sequence the remaining 26070340 samples, and analyze the data for patterns of disease association with small RNA molecules in the prediabetic, perionset, and immediate post onset period. These patterns may identify biomarker small RNA predictive of autoimmune flares or beta cell loss, including predicting impending clinical onset.

2022-10-30 | GSE216551 | GEO

Transcriptomic profile of Lin negative, LEPR positive cells of human peri-implant fibrous tissue and peri-implant bone

Project description:Peri-implant fibrosis is one of the most common reasons for implant failure and surgical revision after prosthetic joint replacement. This type of surgical revisionis associated with substantial additional morbidity and healthcare costs. However, the cellular and molecular mediators of peri-implant fibrosis remain unclear. Here, we show that peri-implant fibrotic tissue in mice and humans is largely composed of a specific population of leptin receptor-expressing(LEPR+) cells and that these LEPR+cells are necessary and sufficient to both generate and maintain peri-implant fibrotic tissue. Genetic ablation of LEPR+cells prevents peri-implant fibrosis, and implantation of LEPR+cells from peri-implant fibrotic tissue is sufficient to induce fibrosis in secondary hosts. We further identify adhesion G protein-coupled receptorF5 (ADGRF5) as a crucial mediator of the fibrotic response by LEPR+cells, as conditional deletion of ADGRF5 in LEPR+cells attenuates peri-implant fibrosis while augmenting peri-implant bone formation. Finally, we demonstrate that inhibition of ADGRF5 by intra articular or systemic administration of neutralizing anti-ADGRF5prevents and reverses peri-implant fibrosis. Thus, pharmaceutical agents that inhibit the ADGRF5 pathway inLEPR+cells may represent a new approach to prevent and treat peri-implant fibrosis.

2024-03-10 | GSE227128 | GEO

Transcriptomic profile of Lin negative, LEPR positive cells of murine peri-implant fibrous tissue and peri-implant bone

Project description:To investigate the transcriptomic profile difference between LEPR cells in peri-implant fibrous tissue and peri-implant bone

2024-03-21 | GSE227869 | GEO

Comparison of the gene expression of periimplantitis affected peri-implant tissue and healthy peri-implant tissue in vivo in human.

Project description:In this study we want to ascertain the differences and similarities of infected and inflammated peri implant tissue versus healthy peri implant tissue at the mRNA level. Six of the patients where affected by periimplantitis. In situ dental implants where explanted because of inflammation and non-integration. From two patients, implants were explanted because of wrong placement. They where classified as implants with healthy periimplant tissue.

2014-05-14 | E-GEOD-57631 | biostudies-arrayexpress

Differential gene expression in peri-infarct neurons of 15-HETrE-administered mice (compared with vehicle-administered mice) on day 4 after ischemic stroke onset

Project description:To investigate the gene expression difference in peri-infarct neurons of vehicle- and 15-HETrE-administered mice on day 4 after ischemic stroke onset, we performed gene expression profiling analysis using data obtained from RNA-seq of peri-infarct neurons collected from the brain of vehicle- and 15-HETrE-administered mice.

2023-07-24 | GSE231400 | GEO

Scgb1a1, Lpo and Gbp2 is Characteristically Expressed in Rat Peri-Implant Epithelium.

Project description:The peri-implant epithelium plays an important role in the prevention against initial stage of inflammation. In order to minimize the risk of peri-implantitis, it is necessary to understand the biological characteristics of the peri-implant epithelium. The aim of this study was to investigate the characteristic gene expression profile of peri-implant epithelium as compared to junctional epithelium using laser microdissection and microarray analysis. Left upper first molars of 4 week-old rat were extracted, and titanium alloy implants were placed. Four weeks after surgery, samples were harvested by laser microdissection, and total RNA samples were isolated. Comprehensive analyses of genes expressed in the junctional epithelium and peri-implant epithelium were performed using microarray analysis. Confirmation of the differential expression of selected genes was performed by quantitative real-time polymerase chain reaction and immunohistochemistry.

2014-04-08 | E-GEOD-56533 | biostudies-arrayexpress

Prospective cohort carriage study

Project description:Prospective cohort carriage study

| PRJEB53187 | ENA

IRSN-23 Prospective Analyses

Project description:IRSN-23 Prospective Analyses

| PRJNA962905 | ENA

Comparison of the gene expression of periimplantitis affected peri-implant tissue and healthy peri-implant tissue in vivo in human.

Project description:In this study we want to ascertain the differences and similarities of infected and inflammated peri implant tissue versus healthy peri implant tissue at the mRNA level.

2014-05-14 | GSE57631 | GEO

Peri-pancreatic LN cDC1 KPC

Project description:Bulk RNA sequencing of sorted peri-pancreatic LN cDC1s from different stages of neoplastic development in the KPC mouse model of pancreatic adenocarcinoma.

2020-04-15 | GSE126361 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data